Longitudinal analysis of cytokine expression during neoadjuvant chemoradiotherapy and subsequent surgery in esophageal cancer patients

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Abstract

BACKGROUND: The purpose of this study was to provide more insight in the course of cytokine concentrations related to pathologic response (pR) and complications after neoadjuvant chemoradiotherapy (NCRT) and esophagectomy in esophageal cancer patients.

METHODS: Patients treated with NCRT followed by transthoracic esophagectomy (n = 35) or transthoracic esophagectomy alone (n = 8) were included. Eight different cytokine concentrations were determined during NCRT, esophagectomy, and the first postoperative week.

RESULTS: Platelet-activating factor before NCRT was associated with pR (P = .011) and remained elevated in patients with a better response. Concentrations of intestinal fatty acid-binding protein and angiopoietin 1 (Ang-1) were different between patients with and without NCRT. Decreased concentrations of Ang-1 on the third postoperative day were associated with postoperative complications (P = .046).

CONCLUSIONS: In this observational study, elevated platelet-activating factor concentrations before NCRT were associated with pR. NCRT is associated with decreased Ang-1 concentrations, whereas reduced Ang-1 concentrations were associated with postoperative complications. (C) 2016 Elsevier Inc. All rights reserved.

Original languageEnglish
Pages (from-to)89-95
Number of pages7
JournalAmerican Journal of Surgery
Volume212
Issue number1
DOIs
Publication statusPublished - Jul-2016

Keywords

  • Esophagectomy
  • Cytokine
  • Neoadjuvant chemoradiotherapy
  • ACTIVATING-FACTOR RECEPTOR
  • SQUAMOUS-CELL CARCINOMA
  • PREOPERATIVE CHEMORADIOTHERAPY
  • IMMUNE-RESPONSES
  • RECTAL-CANCER
  • CHEMOTHERAPY
  • PREDICTION
  • SURVIVAL

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