TY - JOUR
T1 - Longitudinal analysis of cytokine expression during neoadjuvant chemoradiotherapy and subsequent surgery in esophageal cancer patients
AU - Bosch, Dirk J.
AU - Wang, Da
AU - Nijsten, Maarten W. N.
AU - Mul, Veronique E. M.
AU - Hospers, Geke A.P.
AU - Burgerhof, Johannes G. M.
AU - Struys, Michel M. R. F.
AU - Plukker, John Th. M.
PY - 2016/7
Y1 - 2016/7
N2 - BACKGROUND: The purpose of this study was to provide more insight in the course of cytokine concentrations related to pathologic response (pR) and complications after neoadjuvant chemoradiotherapy (NCRT) and esophagectomy in esophageal cancer patients.METHODS: Patients treated with NCRT followed by transthoracic esophagectomy (n = 35) or transthoracic esophagectomy alone (n = 8) were included. Eight different cytokine concentrations were determined during NCRT, esophagectomy, and the first postoperative week.RESULTS: Platelet-activating factor before NCRT was associated with pR (P = .011) and remained elevated in patients with a better response. Concentrations of intestinal fatty acid-binding protein and angiopoietin 1 (Ang-1) were different between patients with and without NCRT. Decreased concentrations of Ang-1 on the third postoperative day were associated with postoperative complications (P = .046).CONCLUSIONS: In this observational study, elevated platelet-activating factor concentrations before NCRT were associated with pR. NCRT is associated with decreased Ang-1 concentrations, whereas reduced Ang-1 concentrations were associated with postoperative complications. (C) 2016 Elsevier Inc. All rights reserved.
AB - BACKGROUND: The purpose of this study was to provide more insight in the course of cytokine concentrations related to pathologic response (pR) and complications after neoadjuvant chemoradiotherapy (NCRT) and esophagectomy in esophageal cancer patients.METHODS: Patients treated with NCRT followed by transthoracic esophagectomy (n = 35) or transthoracic esophagectomy alone (n = 8) were included. Eight different cytokine concentrations were determined during NCRT, esophagectomy, and the first postoperative week.RESULTS: Platelet-activating factor before NCRT was associated with pR (P = .011) and remained elevated in patients with a better response. Concentrations of intestinal fatty acid-binding protein and angiopoietin 1 (Ang-1) were different between patients with and without NCRT. Decreased concentrations of Ang-1 on the third postoperative day were associated with postoperative complications (P = .046).CONCLUSIONS: In this observational study, elevated platelet-activating factor concentrations before NCRT were associated with pR. NCRT is associated with decreased Ang-1 concentrations, whereas reduced Ang-1 concentrations were associated with postoperative complications. (C) 2016 Elsevier Inc. All rights reserved.
KW - Esophagectomy
KW - Cytokine
KW - Neoadjuvant chemoradiotherapy
KW - ACTIVATING-FACTOR RECEPTOR
KW - SQUAMOUS-CELL CARCINOMA
KW - PREOPERATIVE CHEMORADIOTHERAPY
KW - IMMUNE-RESPONSES
KW - RECTAL-CANCER
KW - CHEMOTHERAPY
KW - PREDICTION
KW - SURVIVAL
U2 - 10.1016/j.amjsurg.2015.12.021
DO - 10.1016/j.amjsurg.2015.12.021
M3 - Article
SN - 0002-9610
VL - 212
SP - 89
EP - 95
JO - American Journal of Surgery
JF - American Journal of Surgery
IS - 1
ER -