Low HLA-DR expression on monocytes as a prognostic marker for bacterial sepsis after liver transplantation

JMM VandenBerk; RHJ Oldenbruger; AP VandenBerg; IJ Klompmaker; G Mesander; WJ VanSon; W VanderBij; MJH Slooff; TH The

Low HLA-DR expression on monocytes as a prognostic marker for bacterial sepsis after liver transplantation

JMM VandenBerk
, RHJ Oldenbruger
, AP VandenBerg
, IJ Klompmaker
, G Mesander
, WJ VanSon
, W VanderBij
, MJH Slooff
, TH The

Research output: Contribution to journal › Article › Academic › peer-review

65 Citations (Scopus)

Abstract

Background. Low HLA-DR expression on monocytes is associated with an increased risk of infection after surgery or trauma. We determined the value of this parameter as a marker for sepsis after liver transplantation.

Methods. The percentage of monocytes expressing HLA-DR was determined by flow cytometry before and after liver transplantation in nine patients. Five lung and 20 kidney transplant recipients served as controls.

Results. Bacterial sepsis occurred in 5 of 9 liver transplant patients and 0 of 24 control patients. Monocyte HLA-DR expression decreased 50% in the four liver transplant patients without sepsis. Only 1 of 25 control patients had persistently low monocyte HLA-DR expression.

Conclusions. Monitoring of monocyte HLA-DR expression may be helpful in identifying liver transplant patients who have an increased risk of imminent bacterial sepsis.

Original language	English
Pages (from-to)	1846-1848
Number of pages	3
Journal	Transplantation
Volume	63
Issue number	12
Publication status	Published - 27-Jun-1997

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@article{3a689cb7f8d6403bb748915837a55656,

title = "Low HLA-DR expression on monocytes as a prognostic marker for bacterial sepsis after liver transplantation",

abstract = "Background. Low HLA-DR expression on monocytes is associated with an increased risk of infection after surgery or trauma. We determined the value of this parameter as a marker for sepsis after liver transplantation.Methods. The percentage of monocytes expressing HLA-DR was determined by flow cytometry before and after liver transplantation in nine patients. Five lung and 20 kidney transplant recipients served as controls.Results. Bacterial sepsis occurred in 5 of 9 liver transplant patients and 0 of 24 control patients. Monocyte HLA-DR expression decreased 50\% in the four liver transplant patients without sepsis. Only 1 of 25 control patients had persistently low monocyte HLA-DR expression.Conclusions. Monitoring of monocyte HLA-DR expression may be helpful in identifying liver transplant patients who have an increased risk of imminent bacterial sepsis.",

author = "JMM VandenBerk and RHJ Oldenbruger and AP VandenBerg and IJ Klompmaker and G Mesander and WJ VanSon and W VanderBij and MJH Slooff and TH The",

year = "1997",

month = jun,

day = "27",

language = "English",

volume = "63",

pages = "1846--1848",

journal = "Transplantation",

issn = "0041-1337",

publisher = "Lippincott Williams and Wilkins",

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TY - JOUR

T1 - Low HLA-DR expression on monocytes as a prognostic marker for bacterial sepsis after liver transplantation

AU - VandenBerk, JMM

AU - Oldenbruger, RHJ

AU - VandenBerg, AP

AU - Klompmaker, IJ

AU - Mesander, G

AU - VanSon, WJ

AU - VanderBij, W

AU - Slooff, MJH

AU - The, TH

PY - 1997/6/27

Y1 - 1997/6/27

N2 - Background. Low HLA-DR expression on monocytes is associated with an increased risk of infection after surgery or trauma. We determined the value of this parameter as a marker for sepsis after liver transplantation.Methods. The percentage of monocytes expressing HLA-DR was determined by flow cytometry before and after liver transplantation in nine patients. Five lung and 20 kidney transplant recipients served as controls.Results. Bacterial sepsis occurred in 5 of 9 liver transplant patients and 0 of 24 control patients. Monocyte HLA-DR expression decreased 50% in the four liver transplant patients without sepsis. Only 1 of 25 control patients had persistently low monocyte HLA-DR expression.Conclusions. Monitoring of monocyte HLA-DR expression may be helpful in identifying liver transplant patients who have an increased risk of imminent bacterial sepsis.

AB - Background. Low HLA-DR expression on monocytes is associated with an increased risk of infection after surgery or trauma. We determined the value of this parameter as a marker for sepsis after liver transplantation.Methods. The percentage of monocytes expressing HLA-DR was determined by flow cytometry before and after liver transplantation in nine patients. Five lung and 20 kidney transplant recipients served as controls.Results. Bacterial sepsis occurred in 5 of 9 liver transplant patients and 0 of 24 control patients. Monocyte HLA-DR expression decreased 50% in the four liver transplant patients without sepsis. Only 1 of 25 control patients had persistently low monocyte HLA-DR expression.Conclusions. Monitoring of monocyte HLA-DR expression may be helpful in identifying liver transplant patients who have an increased risk of imminent bacterial sepsis.

M3 - Article

SN - 0041-1337

VL - 63

SP - 1846

EP - 1848

JO - Transplantation

JF - Transplantation

IS - 12

ER -

Low HLA-DR expression on monocytes as a prognostic marker for bacterial sepsis after liver transplantation

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