Low-threshold calcium current in dendrites of the adult rat hippocampus

H KARST*, M JOELS, WJ WADMAN

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

62 Citations (Scopus)

Abstract

The patch-clamp technique was employed in hippocampal slices to examine the characteristics of a low-threshold Ca current in adult CA1 pyramidal neurons. We found that adult CA1 pyramidal neurons possess a distinct transient low-threshold Ca current, located predominantly in the distal dendrites. Surgical cuts that separated the dendrites from the soma and left a dendritic length of 150 mu m, completely abolished the low-threshold Ca current while a transient K current persisted even in cells with dendrites as short as 50 mu m. The transient low-threshold Ca current in dendrites may represent a voltage-dependent Ca entry pathway which contributes to the regulation of cellular excitability, plasticity and pathology.

Original languageEnglish
Pages (from-to)154-158
Number of pages5
JournalNeuroscience Letters
Volume164
Issue number1-2
DOIs
Publication statusPublished - 24-Dec-1993
Externally publishedYes

Keywords

  • LOW-THRESHOLD CALCIUM CONDUCTANCE
  • CA1 AREA
  • HIPPOCAMPAL SLICE
  • PATCH CLAMP
  • CELL PATCH-CLAMP
  • PYRAMIDAL NEURONS
  • GUINEA-PIG
  • KINETIC-PROPERTIES
  • CHANNELS
  • VOLTAGE
  • CONDUCTANCES

Cite this