Low-volume PEG plus ascorbic acid versus high-volume PEG as bowel preparation for colonoscopy

Sietske Corporaal*, Jan H. Kleibeuker, Jan J. Koornstra

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

93 Citations (Scopus)

Abstract

Objective. High volumes of polyethylene glycol (PEG)-based solutions as bowel preparation for colonoscopy are effective, but often poorly tolerated. To compare a 2 l PEG-based solution combined with ascorbic acid (PEG + Asc) with 4 l PEG-based solution (PEG). Methods. In a single blind, quasi-randomized, prospective study, 350 patients undergoing colonoscopy received 2 l of PEG + Asc or 4 l of PEG. For morning procedures, the total dose of PEG + Asc was taken the evening before, for afternoon colonoscopies, PEG + Asc was given as a split dose. The 4 l PEG preparation was given as a split dose. Efficacy of preparation was scored on a five-point scale in three different colon segments. Patients' experiences were evaluated using a questionnaire. Results. From 307 patients (149 PEG + Asc, 158 PEG), results were available. Successful colon cleansing was achieved in 90.6% in the PEG + Asc group compared to 96% in the PEG group (not significant). In patients prepared with PEG + Asc, bowel cleansing was worse when patients underwent colonoscopy in the morning, compared to afternoon procedures. Side-effects and patients' experiences were similar in the PEG + Asc and PEG group. Conclusions. Low-volume PEG + ascorbic acid has comparable efficacy and tolerability as high-volume PEG solution. The cleansing results were worse if patients received the full dose PEG + Asc the evening before the procedure compared to the split dose. Our data support the administration of PEG + Asc as a split dose before the procedure.

Original languageEnglish
Pages (from-to)1380-1386
Number of pages7
JournalSCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
Volume45
Issue number11
DOIs
Publication statusPublished - Nov-2010

Keywords

  • Ascorbic acid
  • bowel preparation
  • colonoscopy
  • polyethylene glycol
  • ORAL SODIUM-PHOSPHATE
  • POLYETHYLENE-GLYCOL
  • ELECTROLYTE-SOLUTION
  • PROSPECTIVE TRIAL
  • QUALITY
  • EFFICACY
  • SAFETY
  • MULTICENTER
  • LAVAGE
  • IMPACT

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