Lower-Extremity Function in Cognitively Healthy Aging, Mild Cognitive Impairment, and Alzheimer's Disease

Laura H. Eggermont, Brandon E. Gavett, Karin M. Volkers, Christiaan G. Blankevoort, Erik J. Scherder, Angela L. Jefferson, Eric Steinberg, Anil Nair, Robert C. Green, Robert A. Stern*

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

    104 Citations (Scopus)

    Abstract

    Eggermont LH, Gavett BE, Volkers KM, Blankevoort CG, Scherder EJ, Jefferson AL, Steinberg E, Nair A, Green RC, Stern RA. Lower-extremity function in cognitively healthy aging, mild cognitive impairment, and Alzheimer's disease. Arch Phys Med Rehabil 2010;91:584-8.

    Objective: To examine differences in lower-extremity function in cognitive healthy older persons, older persons with mild cognitive impairment (MCI), and older persons with Alzheimer's disease (AD).

    Design: Descriptive study.

    Setting: University Alzheimer's disease clinical and research program.

    Participants: Older persons (N=66) were studied (mean age, 76.7y); 22 were cognitively normal, 22 were diagnosed with probable MCI, 22 were diagnosed with probable AD.

    Interventions: Not applicable.

    Main Outcome Measures: Lower-extremity function was assessed by the four-meter walk test (4MWT), Timed Up & Go (TUG) test, and sit-to-stand (STS) test.

    Results: Analysis of variance, adjusting for covariates, revealed that performance on the 4MWT was significantly lower in the MCI and AD groups as compared with controls. TUG test performance was worse in the AD group compared with controls. No significant group differences were found for STS performance.

    Conclusions: These results suggest an association between cognitive impairment and lower-limb function in older persons. Walking speed could be evaluated for its possible utility in screening older persons at risk for cognitive impairment and falls.

    Original languageEnglish
    Pages (from-to)584-588
    Number of pages5
    JournalArchives of Physical Medicine and Rehabilitation
    Volume91
    Issue number4
    DOIs
    Publication statusPublished - Apr-2010

    Keywords

    • Aging
    • Alzheimer disease
    • Cognition
    • Gait
    • Rehabilitation
    • FRAIL ELDERLY-PATIENTS
    • GAIT VELOCITY
    • DIVIDED ATTENTION
    • MOTOR DYSFUNCTION
    • STAND TEST
    • GO TEST
    • COMMUNITY
    • DEMENTIA
    • OLDER
    • PERFORMANCE

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