Lower HDL-C and apolipoprotein A-I are related to higher glomerular filtration rate in subjects without kidney disease

Animal experiments show that the kidney contributes to apolipoprotein (apo) A-I catabolism. We tested relationships of HDL cholesterol (HDL-C) and apo-I with kidney function in subjects without severe chronic kidney disease. Included was a random sample of the general population (part of the PREVEND cohort). Kidney function [estimated glomerular filtration rate (e-GFR) by two well-established equations and creatinine clearance], HDL-C, triglycerides, apoA-I and insulin resistance (HOMA(ir)) were measured in 2,484 fasting subjects (e-GFR >= 45 ml/min/1.73m(2)) without macroalbuminuria, cardiovascular disease, diabetes, or the use of anti-hypertensives and/or lipid-lowering agents. HDL-C (r = -0.056 to -0.102, P <0.01 to <0.001) and apo A-I (r = -0.096 to -0.126, P <0.001) were correlated inversely with both GFR estimates and creatinine clearance in univariate analyses. Multiple linear regression analyses also demonstrated inverse relationships of HDL-C and apoA-I with all measures of kidney function even after adjustment for age, sex, waist circumference, HOMA(ir), triglycerides, and urinary albumin excretion (P = 0.053 to 0.004).jlr In conclusion, HDL-C and apoA-I are inversely related to e-GFR and creatinine clearance in subjects without severely compromised kidney function, which fits the concept that the kidney contributes to apoA-I regulation in humans. High glomerular filtration rate may be an independent determinant of a pro-atherogenic lipoprotein profile.-Krikken, J. A., R. T. Gansevoort, and R. P. F Dullaart on behalf of the PREVEND Study Group. Lower HDL-C and apolipoprotein A-I are related to higher glomerular filtration rate in subjects without kidney disease. J. Lipid Res. 2010. 51: 1982-1990.