Lymphadenopathy driven by TCR-Vγ8Vδ1 T-cell expansion in FAS-related autoimmune lymphoproliferative syndrome

Stefano Vavassori; Jacob D Galson; Johannes Trück; Anke van den Berg; Rienk Y J Tamminga; Aude Magerus-Chatinet; Olivier Pellé; Ulrike Camenisch Gross; Ewerton Marques Maggio; Seraina Prader; Lennart Opitz; Ursina Nüesch; Andrea Mauracher; Benjamin Volkmer; Oliver Speer; Luzia Suda; Benno Röthlisberger; Dieter Robert Zimmermann; Rouven Müller; Arjan Diepstra; Lydia Visser; Eugenia Haralambieva; Bénédicte Neven; Frédéric Rieux-Laucat; Jana Pachlopnik Schmid

doi:10.1182/bloodadvances.2017006411

Lymphadenopathy driven by TCR-Vγ8Vδ1 T-cell expansion in FAS-related autoimmune lymphoproliferative syndrome

Stefano Vavassori, Jacob D Galson, Johannes Trück, Anke van den Berg, Rienk Y J Tamminga, Aude Magerus-Chatinet, Olivier Pellé, Ulrike Camenisch Gross, Ewerton Marques Maggio, Seraina Prader, Lennart Opitz, Ursina Nüesch, Andrea Mauracher, Benjamin Volkmer, Oliver Speer, Luzia Suda, Benno Röthlisberger, Dieter Robert Zimmermann, Rouven Müller, Arjan DiepstraLydia Visser, Eugenia Haralambieva, Bénédicte Neven, Frédéric Rieux-Laucat, Jana Pachlopnik Schmid

Translational Immunology Groningen (TRIGR)

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Abstract

FAS-dependent apoptosis in Vδ1 T cells makes the latter possible culprits for the lymphadenopathy observed in patients with FAS mutations.Rapamycin and methylprednisolone resistance should prompt clinicians to look for Vδ1 T cell proliferation in ALPS-FAS patients.

Original language	English
Pages (from-to)	1101-1106
Number of pages	6
Journal	Blood
Volume	1
Issue number	15
DOIs	https://doi.org/10.1182/bloodadvances.2017006411
Publication status	Published - 27-Jun-2017

Keywords

Journal Article
SCLEROSIS PATIENTS
PERIPHERAL-BLOOD
MUTATIONS
GENES
CYTOMEGALOVIRUS
PYRIMETHAMINE
ORGANIZATION
REPERTOIRE
APOPTOSIS
FAMILIES

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Lymphadenopathy driven by TCR-Vγ8Vδ1 T-cell expansion in FAS-related autoimmune lymphoproliferative syndromeFinal publisher's version, 1.92 MBLicence: Taverne

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Vavassori, S., Galson, J. D., Trück, J., van den Berg, A., Tamminga, R. Y. J., Magerus-Chatinet, A., Pellé, O., Camenisch Gross, U., Marques Maggio, E., Prader, S., Opitz, L., Nüesch, U., Mauracher, A., Volkmer, B., Speer, O., Suda, L., Röthlisberger, B., Zimmermann, D. R., Müller, R., ... Pachlopnik Schmid, J. (2017). Lymphadenopathy driven by TCR-Vγ8Vδ1 T-cell expansion in FAS-related autoimmune lymphoproliferative syndrome. Blood, 1(15), 1101-1106. https://doi.org/10.1182/bloodadvances.2017006411

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title = "Lymphadenopathy driven by TCR-Vγ8Vδ1 T-cell expansion in FAS-related autoimmune lymphoproliferative syndrome",

abstract = "FAS-dependent apoptosis in Vδ1 T cells makes the latter possible culprits for the lymphadenopathy observed in patients with FAS mutations.Rapamycin and methylprednisolone resistance should prompt clinicians to look for Vδ1 T cell proliferation in ALPS-FAS patients.",

keywords = "Journal Article, SCLEROSIS PATIENTS, PERIPHERAL-BLOOD, MUTATIONS, GENES, CYTOMEGALOVIRUS, PYRIMETHAMINE, ORGANIZATION, REPERTOIRE, APOPTOSIS, FAMILIES",

author = "Stefano Vavassori and Galson, {Jacob D} and Johannes Tr{\"u}ck and {van den Berg}, Anke and Tamminga, {Rienk Y J} and Aude Magerus-Chatinet and Olivier Pell{\'e} and {Camenisch Gross}, Ulrike and {Marques Maggio}, Ewerton and Seraina Prader and Lennart Opitz and Ursina N{\"u}esch and Andrea Mauracher and Benjamin Volkmer and Oliver Speer and Luzia Suda and Benno R{\"o}thlisberger and Zimmermann, {Dieter Robert} and Rouven M{\"u}ller and Arjan Diepstra and Lydia Visser and Eugenia Haralambieva and B{\'e}n{\'e}dicte Neven and Fr{\'e}d{\'e}ric Rieux-Laucat and {Pachlopnik Schmid}, Jana",

year = "2017",

month = jun,

day = "27",

doi = "10.1182/bloodadvances.2017006411",

language = "English",

volume = "1",

pages = "1101--1106",

journal = "Blood",

issn = "0006-4971",

publisher = "AMER SOC HEMATOLOGY",

number = "15",

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Vavassori, S, Galson, JD, Trück, J, van den Berg, A , Tamminga, RYJ, Magerus-Chatinet, A, Pellé, O, Camenisch Gross, U, Marques Maggio, E, Prader, S, Opitz, L, Nüesch, U, Mauracher, A, Volkmer, B, Speer, O, Suda, L, Röthlisberger, B, Zimmermann, DR, Müller, R, Diepstra, A , Visser, L, Haralambieva, E, Neven, B, Rieux-Laucat, F & Pachlopnik Schmid, J 2017, 'Lymphadenopathy driven by TCR-Vγ8Vδ1 T-cell expansion in FAS-related autoimmune lymphoproliferative syndrome', Blood, vol. 1, no. 15, pp. 1101-1106. https://doi.org/10.1182/bloodadvances.2017006411

TY - JOUR

T1 - Lymphadenopathy driven by TCR-Vγ8Vδ1 T-cell expansion in FAS-related autoimmune lymphoproliferative syndrome

AU - Vavassori, Stefano

AU - Galson, Jacob D

AU - Trück, Johannes

AU - van den Berg, Anke

AU - Tamminga, Rienk Y J

AU - Magerus-Chatinet, Aude

AU - Pellé, Olivier

AU - Camenisch Gross, Ulrike

AU - Marques Maggio, Ewerton

AU - Prader, Seraina

AU - Opitz, Lennart

AU - Nüesch, Ursina

AU - Mauracher, Andrea

AU - Volkmer, Benjamin

AU - Speer, Oliver

AU - Suda, Luzia

AU - Röthlisberger, Benno

AU - Zimmermann, Dieter Robert

AU - Müller, Rouven

AU - Diepstra, Arjan

AU - Visser, Lydia

AU - Haralambieva, Eugenia

AU - Neven, Bénédicte

AU - Rieux-Laucat, Frédéric

AU - Pachlopnik Schmid, Jana

PY - 2017/6/27

Y1 - 2017/6/27

N2 - FAS-dependent apoptosis in Vδ1 T cells makes the latter possible culprits for the lymphadenopathy observed in patients with FAS mutations.Rapamycin and methylprednisolone resistance should prompt clinicians to look for Vδ1 T cell proliferation in ALPS-FAS patients.

AB - FAS-dependent apoptosis in Vδ1 T cells makes the latter possible culprits for the lymphadenopathy observed in patients with FAS mutations.Rapamycin and methylprednisolone resistance should prompt clinicians to look for Vδ1 T cell proliferation in ALPS-FAS patients.

KW - Journal Article

KW - SCLEROSIS PATIENTS

KW - PERIPHERAL-BLOOD

KW - MUTATIONS

KW - GENES

KW - CYTOMEGALOVIRUS

KW - PYRIMETHAMINE

KW - ORGANIZATION

KW - REPERTOIRE

KW - APOPTOSIS

KW - FAMILIES

U2 - 10.1182/bloodadvances.2017006411

DO - 10.1182/bloodadvances.2017006411

M3 - Article

C2 - 29296752

SN - 0006-4971

VL - 1

SP - 1101

EP - 1106

JO - Blood

JF - Blood

IS - 15

ER -

Lymphadenopathy driven by TCR-Vγ8Vδ1 T-cell expansion in FAS-related autoimmune lymphoproliferative syndrome

Abstract

Keywords

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