Lymphadenopathy driven by TCR-Vγ8Vδ1 T-cell expansion in FAS-related autoimmune lymphoproliferative syndrome

Stefano Vavassori, Jacob D Galson, Johannes Trück, Anke van den Berg, Rienk Y J Tamminga, Aude Magerus-Chatinet, Olivier Pellé, Ulrike Camenisch Gross, Ewerton Marques Maggio, Seraina Prader, Lennart Opitz, Ursina Nüesch, Andrea Mauracher, Benjamin Volkmer, Oliver Speer, Luzia Suda, Benno Röthlisberger, Dieter Robert Zimmermann, Rouven Müller, Arjan DiepstraLydia Visser, Eugenia Haralambieva, Bénédicte Neven, Frédéric Rieux-Laucat, Jana Pachlopnik Schmid

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Abstract

FAS-dependent apoptosis in Vδ1 T cells makes the latter possible culprits for the lymphadenopathy observed in patients with FAS mutations.Rapamycin and methylprednisolone resistance should prompt clinicians to look for Vδ1 T cell proliferation in ALPS-FAS patients.

Original languageEnglish
Pages (from-to)1101-1106
Number of pages6
JournalBlood
Volume1
Issue number15
DOIs
Publication statusPublished - 27-Jun-2017

Keywords

  • Journal Article
  • SCLEROSIS PATIENTS
  • PERIPHERAL-BLOOD
  • MUTATIONS
  • GENES
  • CYTOMEGALOVIRUS
  • PYRIMETHAMINE
  • ORGANIZATION
  • REPERTOIRE
  • APOPTOSIS
  • FAMILIES

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