Lysophosphatidic acid: mitogen and motility factor

F N van Leeuwen; B N G Giepmans; L A van Meeteren; W H Moolenaar

doi:10.1042/

Lysophosphatidic acid: mitogen and motility factor

F N van Leeuwen, B N G Giepmans, L A van Meeteren, W H Moolenaar

Research output: Contribution to journal › Article › Academic › peer-review

70 Citations (Scopus)

Abstract

LPA (lysophosphatidic acid), the simplest of al glycerophospholipids, is a potent inducer of cell proliferation, migration and survival. It does so by activating its cognate G-protein-coupled receptors, four of which have been identified. LPA receptors couple to at least three distinct G-proteins and thereby activate multiple signal transduction pathways, particularly those initiated by the small GTPases Ras, Rho and Rac. Our recent work has shown that LPA signals Rac activation via the Tiam1 GDP/GTP exchange factor and thereby stimulates cell migration. Here we discuss recent progress in our understanding of LPA action.

Original language	English
Pages (from-to)	1209-12
Number of pages	4
Journal	Biochemical Society Transactions
Volume	31
Issue number	Pt 6
DOIs	https://doi.org/10.1042/
Publication status	Published - Dec-2003

Keywords

Cell Movement
Enzyme Activation
GTP-Binding Proteins
Lysophospholipids
Mitogen-Activated Protein Kinases
Mitogens
Signal Transduction

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title = "Lysophosphatidic acid: mitogen and motility factor",

abstract = "LPA (lysophosphatidic acid), the simplest of al glycerophospholipids, is a potent inducer of cell proliferation, migration and survival. It does so by activating its cognate G-protein-coupled receptors, four of which have been identified. LPA receptors couple to at least three distinct G-proteins and thereby activate multiple signal transduction pathways, particularly those initiated by the small GTPases Ras, Rho and Rac. Our recent work has shown that LPA signals Rac activation via the Tiam1 GDP/GTP exchange factor and thereby stimulates cell migration. Here we discuss recent progress in our understanding of LPA action.",

keywords = "Cell Movement, Enzyme Activation, GTP-Binding Proteins, Lysophospholipids, Mitogen-Activated Protein Kinases, Mitogens, Signal Transduction",

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year = "2003",

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doi = "10.1042/",

language = "English",

volume = "31",

pages = "1209--12",

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TY - JOUR

T1 - Lysophosphatidic acid

T2 - mitogen and motility factor

AU - van Leeuwen, F N

AU - Giepmans, B N G

AU - van Meeteren, L A

AU - Moolenaar, W H

PY - 2003/12

Y1 - 2003/12

N2 - LPA (lysophosphatidic acid), the simplest of al glycerophospholipids, is a potent inducer of cell proliferation, migration and survival. It does so by activating its cognate G-protein-coupled receptors, four of which have been identified. LPA receptors couple to at least three distinct G-proteins and thereby activate multiple signal transduction pathways, particularly those initiated by the small GTPases Ras, Rho and Rac. Our recent work has shown that LPA signals Rac activation via the Tiam1 GDP/GTP exchange factor and thereby stimulates cell migration. Here we discuss recent progress in our understanding of LPA action.

AB - LPA (lysophosphatidic acid), the simplest of al glycerophospholipids, is a potent inducer of cell proliferation, migration and survival. It does so by activating its cognate G-protein-coupled receptors, four of which have been identified. LPA receptors couple to at least three distinct G-proteins and thereby activate multiple signal transduction pathways, particularly those initiated by the small GTPases Ras, Rho and Rac. Our recent work has shown that LPA signals Rac activation via the Tiam1 GDP/GTP exchange factor and thereby stimulates cell migration. Here we discuss recent progress in our understanding of LPA action.

KW - Cell Movement

KW - Enzyme Activation

KW - GTP-Binding Proteins

KW - Lysophospholipids

KW - Mitogen-Activated Protein Kinases

KW - Mitogens

KW - Signal Transduction

U2 - 10.1042/

DO - 10.1042/

M3 - Article

C2 - 14641027

SN - 0300-5127

VL - 31

SP - 1209

EP - 1212

JO - Biochemical Society Transactions

JF - Biochemical Society Transactions

IS - Pt 6

ER -

Lysophosphatidic acid: mitogen and motility factor

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Keywords

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