Male subfertility and oxidative stress

Emily P. P. Evans; Jorien T. M. Scholten; Aldona Mzyk; Claudia Reyes-San-Martin; Arturo E. Llumbet; Thamir Hamoh; Eus G. J. M. Arts; Romana Schirhagl; Astrid E. P. Cantineau

doi:10.1016/j.redox.2021.102071

Male subfertility and oxidative stress

Emily P. P. Evans, Jorien T. M. Scholten, Aldona Mzyk, Claudia Reyes-San-Martin, Arturo E. Llumbet, Thamir Hamoh, Eus G. J. M. Arts, Romana Schirhagl, Astrid E. P. Cantineau

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Abstract

To date 15% of couples are suffering from infertility with 45-50% of males being responsible. With an increase in paternal age as well as various environmental and lifestyle factors worsening these figures are expected to in-crease. As the so-called free radical theory of infertility suggests, free radicals or reactive oxygen species (ROS) play an essential role in this process. However, ROS also fulfill important functions for instance in sperm maturation. The aim of this review article is to discuss the role reactive oxygen species play in male fertility and how these are influenced by lifestyle, age or disease. We will further discuss how these ROS are measured and how they can be avoided during in-vitro fertilization.

Original language	English
Article number	102071
Number of pages	17
Journal	Redox Biology
Volume	46
DOIs	https://doi.org/10.1016/j.redox.2021.102071
Publication status	Published - Oct-2021

Keywords

Reactive oxygen species
Oxidative stress
Infertility
Subfertility
Sperm
SPERM DNA FRAGMENTATION
OXYGEN SPECIES GENERATION
BIOCONJUGATED GOLD NANOPARTICLES
MAGNETIC CELL-SEPARATION
ZINC-OXIDE NANOPARTICLES
HYALURONIC-ACID BINDING
REDUCED SEMEN QUALITY
HUMAN-SPERMATOZOA
CIGARETTE-SMOKING
IN-VITRO

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title = "Male subfertility and oxidative stress",

abstract = "To date 15% of couples are suffering from infertility with 45-50% of males being responsible. With an increase in paternal age as well as various environmental and lifestyle factors worsening these figures are expected to in-crease. As the so-called free radical theory of infertility suggests, free radicals or reactive oxygen species (ROS) play an essential role in this process. However, ROS also fulfill important functions for instance in sperm maturation. The aim of this review article is to discuss the role reactive oxygen species play in male fertility and how these are influenced by lifestyle, age or disease. We will further discuss how these ROS are measured and how they can be avoided during in-vitro fertilization.",

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author = "Evans, {Emily P. P.} and Scholten, {Jorien T. M.} and Aldona Mzyk and Claudia Reyes-San-Martin and Llumbet, {Arturo E.} and Thamir Hamoh and Arts, {Eus G. J. M.} and Romana Schirhagl and Cantineau, {Astrid E. P.}",

year = "2021",

month = oct,

doi = "10.1016/j.redox.2021.102071",

language = "English",

volume = "46",

journal = "Redox Biology",

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TY - JOUR

T1 - Male subfertility and oxidative stress

AU - Evans, Emily P. P.

AU - Scholten, Jorien T. M.

AU - Mzyk, Aldona

AU - Reyes-San-Martin, Claudia

AU - Llumbet, Arturo E.

AU - Hamoh, Thamir

AU - Arts, Eus G. J. M.

AU - Schirhagl, Romana

AU - Cantineau, Astrid E. P.

PY - 2021/10

Y1 - 2021/10

N2 - To date 15% of couples are suffering from infertility with 45-50% of males being responsible. With an increase in paternal age as well as various environmental and lifestyle factors worsening these figures are expected to in-crease. As the so-called free radical theory of infertility suggests, free radicals or reactive oxygen species (ROS) play an essential role in this process. However, ROS also fulfill important functions for instance in sperm maturation. The aim of this review article is to discuss the role reactive oxygen species play in male fertility and how these are influenced by lifestyle, age or disease. We will further discuss how these ROS are measured and how they can be avoided during in-vitro fertilization.

AB - To date 15% of couples are suffering from infertility with 45-50% of males being responsible. With an increase in paternal age as well as various environmental and lifestyle factors worsening these figures are expected to in-crease. As the so-called free radical theory of infertility suggests, free radicals or reactive oxygen species (ROS) play an essential role in this process. However, ROS also fulfill important functions for instance in sperm maturation. The aim of this review article is to discuss the role reactive oxygen species play in male fertility and how these are influenced by lifestyle, age or disease. We will further discuss how these ROS are measured and how they can be avoided during in-vitro fertilization.

KW - Reactive oxygen species

KW - Oxidative stress

KW - Infertility

KW - Subfertility

KW - Sperm

KW - SPERM DNA FRAGMENTATION

KW - OXYGEN SPECIES GENERATION

KW - BIOCONJUGATED GOLD NANOPARTICLES

KW - MAGNETIC CELL-SEPARATION

KW - ZINC-OXIDE NANOPARTICLES

KW - HYALURONIC-ACID BINDING

KW - REDUCED SEMEN QUALITY

KW - HUMAN-SPERMATOZOA

KW - CIGARETTE-SMOKING

KW - IN-VITRO

U2 - 10.1016/j.redox.2021.102071

DO - 10.1016/j.redox.2021.102071

M3 - Article

VL - 46

JO - Redox Biology

JF - Redox Biology

SN - 2213-2317

M1 - 102071

ER -