Male subfertility and oxidative stress

Emily P. P. Evans, Jorien T. M. Scholten, Aldona Mzyk, Claudia Reyes-San-Martin, Arturo E. Llumbet, Thamir Hamoh, Eus G. J. M. Arts, Romana Schirhagl, Astrid E. P. Cantineau

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Abstract

To date 15% of couples are suffering from infertility with 45-50% of males being responsible. With an increase in paternal age as well as various environmental and lifestyle factors worsening these figures are expected to in-crease. As the so-called free radical theory of infertility suggests, free radicals or reactive oxygen species (ROS) play an essential role in this process. However, ROS also fulfill important functions for instance in sperm maturation. The aim of this review article is to discuss the role reactive oxygen species play in male fertility and how these are influenced by lifestyle, age or disease. We will further discuss how these ROS are measured and how they can be avoided during in-vitro fertilization.

Original languageEnglish
Article number102071
Number of pages17
JournalRedox Biology
Volume46
DOIs
Publication statusPublished - Oct-2021

Keywords

  • Reactive oxygen species
  • Oxidative stress
  • Infertility
  • Subfertility
  • Sperm
  • SPERM DNA FRAGMENTATION
  • OXYGEN SPECIES GENERATION
  • BIOCONJUGATED GOLD NANOPARTICLES
  • MAGNETIC CELL-SEPARATION
  • ZINC-OXIDE NANOPARTICLES
  • HYALURONIC-ACID BINDING
  • REDUCED SEMEN QUALITY
  • HUMAN-SPERMATOZOA
  • CIGARETTE-SMOKING
  • IN-VITRO

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