Abstract
Purpose: To perform a systematic literature review for critical evaluation of prevalence and factors contributing to malnutrition in childhood cancer.
Methods: A systematic search resulting in 46 suitable articles.
Results: Due to lack of uniform criteria and adequate studies, the prevalence rates of malnutrition can only be estimated. Based on strengths and weaknesses of included references, prevalence rates are estimated to be 0-10% for leukemia, 20-50% for neuroblastoma, and 0-30% for other malignancies. Whether energy deficiency or inflammation contributed to malnutrition could not be confirmed because the occurrence of energy deficit (low energy intake, increased metabolic rate) or inflammation (related to cachexia) was not convincing. Also, a relationship between these factors and malnutrition was not studied.
Conclusion: Longitudinal studies are needed to determine which children are at risk of malnutrition, and to investigate the impact of energy deficiency and inflammation on the nutritional status and body composition of childhood cancer patients. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
| Original language | English |
|---|---|
| Pages (from-to) | 249-275 |
| Number of pages | 27 |
| Journal | Critical Reviews in Oncology/Hematology |
| Volume | 83 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Aug-2012 |
Keywords
- Childhood cancer
- Nutritional status
- Malnutrition
- Weight loss
- Energy intake
- Metabolic rate
- Physical activity
- Inflammation
- ACUTE LYMPHOBLASTIC-LEUKEMIA
- PROTEIN-ENERGY MALNUTRITION
- PEDIATRIC ONCOLOGY PATIENTS
- X-RAY ABSORPTIOMETRY
- LEAN BODY-MASS
- STEM-CELL TRANSPLANTATION
- BASAL METABOLIC-RATE
- C-REACTIVE PROTEIN
- NUTRITIONAL-STATUS
- PHYSICAL-ACTIVITY