Abstract
Here we report that chiral Mn(I) complexes are capable of H-P bond activation. This activation mode enables a general method for the hydrophosphination of internal and terminal α,β-unsaturated nitriles. Metal-ligand cooperation, a strategy previously not considered for catalytic H-P bond activation, is at the base of the mechanistic action of the Mn(I)-based catalyst. Our computational studies support a stepwise mechanism for the hydrophosphination and provide insight into the origin of the enantioselectivity.
Original language | English |
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Pages (from-to) | 20071–20076 |
Number of pages | 6 |
Journal | Journal of the American Chemical Society |
Volume | 143 |
Issue number | 48 |
Early online date | 19-Nov-2021 |
DOIs | |
Publication status | Published - 8-Dec-2021 |
Datasets
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CCDC 2085290: Experimental Crystal Structure Determination
Pérez Galera, J. (Contributor), Postolache, R. (Contributor), Castiñeira Reis, M. (Contributor), Sinnema, E. (Contributor), Vargová, D. (Contributor), de Vries, F. (Contributor), Otten, E. (Contributor), Ge, L. (Contributor) & Harutyunyan, S. (Contributor), The Cambridge Structural Database, 22-May-2021
DOI: 10.5517/ccdc.csd.cc27zxfl, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc27zxfl&sid=DataCite
Dataset
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CCDC 2085460: Experimental Crystal Structure Determination
Pérez Galera, J. (Contributor), Postolache, R. (Contributor), Castiñeira Reis, M. (Contributor), Sinnema, E. (Contributor), Vargová, D. (Contributor), de Vries, F. (Contributor), Otten, E. (Contributor), Ge, L. (Contributor) & Harutyunyan, S. (Contributor), The Cambridge Structural Database, 23-May-2021
DOI: 10.5517/ccdc.csd.cc2802x9, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc2802x9&sid=DataCite
Dataset
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CCDC 2120248: Experimental Crystal Structure Determination
Pérez Galera, J. (Contributor), Postolache, R. (Contributor), Castiñeira Reis, M. (Contributor), Sinnema, E. (Contributor), Vargová, D. (Contributor), de Vries, F. (Contributor), Otten, E. (Contributor), Ge, L. (Contributor) & Harutyunyan, S. (Contributor), The Cambridge Structural Database, 4-Nov-2021
DOI: 10.5517/ccdc.csd.cc29593x, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc29593x&sid=DataCite
Dataset