Manganese(I)-Catalyzed H-P Bond Activation via Metal-Ligand Cooperation

Juana M Pérez, Roxana Postolache, Marta Castiñeira Reis, Esther G. Sinnema, Denisa Vargová, Folkert de Vries, Edwin Otten, Luo Ge*, Syuzanna R Harutyunyan*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

44 Citations (Scopus)
157 Downloads (Pure)

Abstract

Here we report that chiral Mn(I) complexes are capable of H-P bond activation. This activation mode enables a general method for the hydrophosphination of internal and terminal α,β-unsaturated nitriles. Metal-ligand cooperation, a strategy previously not considered for catalytic H-P bond activation, is at the base of the mechanistic action of the Mn(I)-based catalyst. Our computational studies support a stepwise mechanism for the hydrophosphination and provide insight into the origin of the enantioselectivity.

Original languageEnglish
Pages (from-to)20071–20076
Number of pages6
JournalJournal of the American Chemical Society
Volume143
Issue number48
Early online date19-Nov-2021
DOIs
Publication statusPublished - 8-Dec-2021

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