Mannan binding lectin: a two-faced regulator of renal allograft injury?

Jeffrey Damman*, Marc A. Seelen

*Corresponding author for this work

Research output: Contribution to journalEditorialAcademicpeer-review

11 Citations (Scopus)

Abstract

Complement activation plays an important role in the pathogenesis of renal allograft injury after kidney transplantation. There are three known pathways of complement activation, namely, classical, alternative, and lectin pathways. In renal allograft injury, contradictory results were reported about the role of the lectin pathway activated via mannan binding lectin (MBL). This Commentary discusses the findings by Bay et al. (this issue), who demonstrated a protective role for circulating MBL in the recipient, particularly in non-HLA immunized recipients. Kidney International (2013) 83, 191-193. doi:10.1038/ki.2012.397

Original languageEnglish
Pages (from-to)191-193
Number of pages3
JournalKidney International
Volume83
Issue number2
DOIs
Publication statusPublished - Feb-2013

Keywords

  • ISCHEMIA/REPERFUSION INJURY
  • KIDNEY-TRANSPLANTATION
  • COMPLEMENT ACTIVATION
  • PATHWAY

Fingerprint

Dive into the research topics of 'Mannan binding lectin: a two-faced regulator of renal allograft injury?'. Together they form a unique fingerprint.

Cite this