Mapping Alzheimer’s disease: Exploring cellular vulnerability and resilience

Natalia Ortí-Casañ; John R. Bethea; Ulrich L.M. Eisel

doi:10.1038/s41392-024-02014-9

Mapping Alzheimer’s disease: Exploring cellular vulnerability and resilience

Natalia Ortí-Casañ, John R. Bethea, Ulrich L.M. Eisel^*

^*Corresponding author for this work

Eisel lab - Molecular Neurobiology and Neuroimmunology

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Abstract

In a recent paper published in Nature, Mathys and co-workers presented a comprehensive and precise transcriptomic atlas of distinct brain regions from individuals with and without Alzheimer’s disease (AD). This paper aimed to identify differences in regional molecular architecture along with region-specific changes in neuronal and glial subtypes, while also investigating whether certain brain regions and cell subtypes are more vulnerable or uniquely affected by AD compared to others, and exploring mechanisms that may contribute to cellular resilience.

Original language	English
Article number	299
Number of pages	3
Journal	Signal transduction and targeted therapy
Volume	9
Issue number	1
DOIs	https://doi.org/10.1038/s41392-024-02014-9
Publication status	Published - 28-Oct-2024

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Mapping Alzheimer’s disease: Exploring cellular vulnerability and resilience

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Stimulation of TNF receptor 2 as effective therapeutic for Alzheimer's disease

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Mapping Alzheimer’s disease: Exploring cellular vulnerability and resilience

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Stimulation of TNF receptor 2 as effective therapeutic for Alzheimer's disease

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