Mapping of 79 loci for 83 plasma protein biomarkers in cardiovascular disease

Lasse Folkersen; Eric Fauman; Maria Sabater-Lleal; Rona J. Strawbridge; Mattias Franberg; Bengt Sennblad; Damiano Baldassarre; Fabrizio Veglia; Steve E. Humphries; Rainer Rauramaa; Ulf de Faire; Andries J. Smit; Philippe Giral; Sudhir Kurl; Elmo Mannarino; Stefan Enroth; Asa Johansson; Sofia Bosdotter Enroth; Stefan Gustafsson; Lars Lind; Cecilia Lindgren; Andrew P. Morris; Vilmantas Giedraitis; Angela Silveira; Anders Franco-Cereceda; Elena Tremoli; Ulf Gyllensten; Erik Ingelsson; Soren Brunak; Per Eriksson; Daniel Ziemek; Anders Hamsten; Anders Malarstig; IMPROVE Study Grp

doi:10.1371/journal.pgen.1006706

Mapping of 79 loci for 83 plasma protein biomarkers in cardiovascular disease

Lasse Folkersen, Eric Fauman, Maria Sabater-Lleal, Rona J. Strawbridge, Mattias Franberg, Bengt Sennblad, Damiano Baldassarre, Fabrizio Veglia, Steve E. Humphries, Rainer Rauramaa, Ulf de Faire, Andries J. Smit, Philippe Giral, Sudhir Kurl, Elmo Mannarino, Stefan Enroth, Asa Johansson, Sofia Bosdotter Enroth, Stefan Gustafsson, Lars LindCecilia Lindgren, Andrew P. Morris, Vilmantas Giedraitis, Angela Silveira, Anders Franco-Cereceda, Elena Tremoli, Ulf Gyllensten, Erik Ingelsson, Soren Brunak, Per Eriksson, Daniel Ziemek, Anders Hamsten, Anders Malarstig^*, IMPROVE Study Grp

^*Corresponding author for this work

Groningen Kidney Center (GKC)

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Recent advances in highly multiplexed immunoassays have allowed systematic large-scale measurement of hundreds of plasma proteins in large cohort studies. In combination with genotyping, such studies offer the prospect to 1) identify mechanisms involved with regulation of protein expression in plasma, and 2) determine whether the plasma proteins are likely to be causally implicated in disease. We report here the results of genome-wide association (GWA) studies of 83 proteins considered relevant to cardiovascular disease (CVD), measured in 3,394 individuals with multiple CVD risk factors. We identified 79 genome-wide significant (p

Original language	English
Number of pages	21
Journal	PLoS genetics
Volume	13
Issue number	4
DOIs	https://doi.org/10.1371/journal.pgen.1006706
Publication status	Published - 3-Apr-2017

Keywords

GENOME-WIDE ASSOCIATION
INTIMA-MEDIA THICKNESS
GENETIC-VARIANTS
MENDELIAN RANDOMIZATION
EXPRESSION
RISK
POPULATION
CELLS
GWAS
LIFE

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Folkersen, L. (Creator), Fauman, E. (Creator), Sabater-Lleal, M. (Creator), Strawbridge, R. J. (Creator), Franberg, M. (Creator), Sennblad, B. (Creator), Baldassarre, D. (Creator), Veglia, F. (Creator), Humphries, S. E. (Creator), Rauramaa, R. (Creator), de Faire, U. (Creator), Smit, A. J. (Creator), Giral, P. (Creator), Kurl, S. (Creator), Mannarino, E. (Creator), Enroth, S. (Creator), Johansson, A. (Creator), Enroth, S. B. (Creator), Gustafsson, S. (Creator), Lind, L. (Creator), Lindgren, C. (Creator), Morris, A. P. (Creator), Giedraitis, V. (Creator), Silveira, A. (Creator), Franco-Cereceda, A. (Creator), Tremoli, E. (Creator), Gyllensten, U. (Creator), Ingelsson, E. (Creator), Brunak, S. (Creator), Eriksson, P. (Creator), Ziemek, D. (Creator), Hamsten, A. (Creator) & Malarstig, A. (Creator), University of Groningen, 1-Mar-2017
DOI: 10.5281/zenodo.264128, http://www.olink-improve.com/
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Folkersen, L., Fauman, E., Sabater-Lleal, M., Strawbridge, R. J., Franberg, M., Sennblad, B., Baldassarre, D., Veglia, F., Humphries, S. E., Rauramaa, R., de Faire, U., Smit, A. J., Giral, P., Kurl, S., Mannarino, E., Enroth, S., Johansson, A., Enroth, S. B., Gustafsson, S., ... IMPROVE Study Grp (2017). Mapping of 79 loci for 83 plasma protein biomarkers in cardiovascular disease. PLoS genetics, 13(4). https://doi.org/10.1371/journal.pgen.1006706

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Folkersen, L, Fauman, E, Sabater-Lleal, M, Strawbridge, RJ, Franberg, M, Sennblad, B, Baldassarre, D, Veglia, F, Humphries, SE, Rauramaa, R, de Faire, U, Smit, AJ, Giral, P, Kurl, S, Mannarino, E, Enroth, S, Johansson, A, Enroth, SB, Gustafsson, S, Lind, L, Lindgren, C, Morris, AP, Giedraitis, V, Silveira, A, Franco-Cereceda, A, Tremoli, E, Gyllensten, U, Ingelsson, E, Brunak, S, Eriksson, P, Ziemek, D, Hamsten, A, Malarstig, A & IMPROVE Study Grp 2017, 'Mapping of 79 loci for 83 plasma protein biomarkers in cardiovascular disease', PLoS genetics, vol. 13, no. 4. https://doi.org/10.1371/journal.pgen.1006706

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T1 - Mapping of 79 loci for 83 plasma protein biomarkers in cardiovascular disease

AU - Folkersen, Lasse

AU - Fauman, Eric

AU - Sabater-Lleal, Maria

AU - Strawbridge, Rona J.

AU - Franberg, Mattias

AU - Sennblad, Bengt

AU - Baldassarre, Damiano

AU - Veglia, Fabrizio

AU - Humphries, Steve E.

AU - Rauramaa, Rainer

AU - de Faire, Ulf

AU - Smit, Andries J.

AU - Giral, Philippe

AU - Kurl, Sudhir

AU - Mannarino, Elmo

AU - Enroth, Stefan

AU - Johansson, Asa

AU - Enroth, Sofia Bosdotter

AU - Gustafsson, Stefan

AU - Lind, Lars

AU - Lindgren, Cecilia

AU - Morris, Andrew P.

AU - Giedraitis, Vilmantas

AU - Silveira, Angela

AU - Franco-Cereceda, Anders

AU - Tremoli, Elena

AU - Gyllensten, Ulf

AU - Ingelsson, Erik

AU - Brunak, Soren

AU - Eriksson, Per

AU - Ziemek, Daniel

AU - Hamsten, Anders

AU - Malarstig, Anders

AU - IMPROVE Study Grp

PY - 2017/4/3

Y1 - 2017/4/3

N2 - Recent advances in highly multiplexed immunoassays have allowed systematic large-scale measurement of hundreds of plasma proteins in large cohort studies. In combination with genotyping, such studies offer the prospect to 1) identify mechanisms involved with regulation of protein expression in plasma, and 2) determine whether the plasma proteins are likely to be causally implicated in disease. We report here the results of genome-wide association (GWA) studies of 83 proteins considered relevant to cardiovascular disease (CVD), measured in 3,394 individuals with multiple CVD risk factors. We identified 79 genome-wide significant (p

AB - Recent advances in highly multiplexed immunoassays have allowed systematic large-scale measurement of hundreds of plasma proteins in large cohort studies. In combination with genotyping, such studies offer the prospect to 1) identify mechanisms involved with regulation of protein expression in plasma, and 2) determine whether the plasma proteins are likely to be causally implicated in disease. We report here the results of genome-wide association (GWA) studies of 83 proteins considered relevant to cardiovascular disease (CVD), measured in 3,394 individuals with multiple CVD risk factors. We identified 79 genome-wide significant (p

KW - GENOME-WIDE ASSOCIATION

KW - INTIMA-MEDIA THICKNESS

KW - GENETIC-VARIANTS

KW - MENDELIAN RANDOMIZATION

KW - EXPRESSION

KW - RISK

KW - POPULATION

KW - CELLS

KW - GWAS

KW - LIFE

U2 - 10.1371/journal.pgen.1006706

DO - 10.1371/journal.pgen.1006706

M3 - Article

C2 - 28369058

SN - 1553-7404

VL - 13

JO - PLoS genetics

JF - PLoS genetics

IS - 4

ER -

Mapping of 79 loci for 83 plasma protein biomarkers in cardiovascular disease

Abstract

Keywords

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