Mastocytosis: A disease at the crossroads of hematology and allergology

Bjorn van Anrooij

    Research output: ThesisThesis fully internal (DIV)

    1161 Downloads (Pure)


    Mastocytosis is a rare disease that combines both allergology and hematology in that patients suffer from malignant white blood cells that induce many of the symptoms of allergic diseases. In this thesis we describe the symptoms these patients suffer from, such: as fatigue, itching, flushing and at times life threatening allergic reactions to insect sting. We also describe how these symptoms and risks affect the quality of life of these mastocytosis patients and how this burden van be measured using symptom scoring forms. Moreover, we describe a model that can help us predicting and identify those patients most at risk of these severe allergic reactions to insect stings. Finally, we describe the effect of a novel ‘chemotherapy’ compound called midostaurin on reducing these allergy like symptoms. Midostaurin appears to be a safe and reasonable effective method for symptom reduction in these severely afflicted mastocytosis patients.
    Original languageEnglish
    QualificationDoctor of Philosophy
    Awarding Institution
    • University of Groningen
    • Kluin-Nelemans, Hanneke, Supervisor
    • Oude Elberink, Hanneke, Co-supervisor
    Award date22-May-2019
    Place of Publication[Groningen]
    Print ISBNs978-94-034-1785-1
    Electronic ISBNs978-94-034-1784-4
    Publication statusPublished - 2019

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