MATERNAL SERUM ALPHA-FETOPROTEIN LEVELS AND FETAL-OUTCOME IN EARLY 2ND-TRIMESTER OLIGOHYDRAMNIOS

FJ LOS*, AM HAGENAARS, J MARRINK, TE COHENOVERBEEK, JLJ GAILLARD, H BRANDENBURG

*Corresponding author for this work

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    Abstract

    Early second-trimester oligohydramnios was associated with normal maternal serum alpha-fetoprotein (MSAFP) levels in nine out of 26 cases (35 per cent). Congenital malformations of the fetal urinary tract resulting in fetal anuria were present in nine cases; in seven of them, normal MSAFP levels were measured. In contrast, normal MSAFP levels were established in only 2 out of the 17 cases without fetal malformations. These data suggest that fetal urine is the major source of elevated AFP in the maternal compartment in early second-trimester oligohydramnios. This is further supported by the lack of any relationship between concentrations of MSAFP non-reactive with Concanavalin A, originating mainly from the yolk sac-derived amniotic fluid AFP pool, and the presence of fetal diuresis. Three out of 26 women had experienced early second-trimester oligohydramnios in a previous pregnancy, suggesting the existence of a recurrence risk for this condition.

    Original languageEnglish
    Pages (from-to)285-292
    Number of pages8
    JournalPrenatal Diagnosis
    Volume12
    Issue number4
    Publication statusPublished - Apr-1992

    Keywords

    • ALPHA-FETOPROTEIN
    • CONCANAVALIN-A
    • FETAL MALFORMATIONS
    • OLIGOHYDRAMNIOS
    • 2ND TRIMESTER
    • PREGNANCY
    • ABNORMALITIES

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