Mbth-like proteins in eukaryotic nrps-catalyzed processes

Roelof Ary Lans Bovenberg; Ulrike Maria Muller; Arnold Jacob Mathieu Driessen; Carsten Pohl; Reto Daniel Zwahlen

Mbth-like proteins in eukaryotic nrps-catalyzed processes

Roelof Ary Lans Bovenberg (Inventor), Ulrike Maria Muller (Inventor), Arnold Jacob Mathieu Driessen (Inventor), Carsten Pohl (Inventor), Reto Daniel Zwahlen (Inventor)

Research output: Patent

Abstract

The present invention relates to a method to improve the production of a secondary metabolite catalyzed by a non-ribosomal peptide synthetase comprising contacting in a eukaryotic host a eukaryotic non-ribosomal peptide synthetase with an MbtH-like protein. The present invention further relates to a composition comprising a eukaryotic non-ribosomal peptide synthetase that is not a hybrid and a prokaryotic MbtH and to a eukaryotic host cell comprising a non-ribosomal peptide synthetase and a polynucleotide allowing the expression of an MbtH-like protein.

Original language	English
Patent number	WO2017178624
Priority date	14/04/2016
Publication status	Published - 19-Oct-2017

Access to Document

https://worldwide.espacenet.com/publicationDetails/originalDocument?CC=WO&NR=2017178624A1&KC=A1&FT=D&ND=3&date=20171019&DB=&locale=en_EP

Cite this

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title = "Mbth-like proteins in eukaryotic nrps-catalyzed processes",

abstract = "The present invention relates to a method to improve the production of a secondary metabolite catalyzed by a non-ribosomal peptide synthetase comprising contacting in a eukaryotic host a eukaryotic non-ribosomal peptide synthetase with an MbtH-like protein. The present invention further relates to a composition comprising a eukaryotic non-ribosomal peptide synthetase that is not a hybrid and a prokaryotic MbtH and to a eukaryotic host cell comprising a non-ribosomal peptide synthetase and a polynucleotide allowing the expression of an MbtH-like protein.",

author = "Bovenberg, {Roelof Ary Lans} and Muller, {Ulrike Maria} and Driessen, {Arnold Jacob Mathieu} and Carsten Pohl and Zwahlen, {Reto Daniel}",

year = "2017",

month = oct,

day = "19",

language = "English",

type = "Patent",

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T1 - Mbth-like proteins in eukaryotic nrps-catalyzed processes

AU - Bovenberg, Roelof Ary Lans

AU - Muller, Ulrike Maria

AU - Driessen, Arnold Jacob Mathieu

AU - Pohl, Carsten

AU - Zwahlen, Reto Daniel

PY - 2017/10/19

Y1 - 2017/10/19

N2 - The present invention relates to a method to improve the production of a secondary metabolite catalyzed by a non-ribosomal peptide synthetase comprising contacting in a eukaryotic host a eukaryotic non-ribosomal peptide synthetase with an MbtH-like protein. The present invention further relates to a composition comprising a eukaryotic non-ribosomal peptide synthetase that is not a hybrid and a prokaryotic MbtH and to a eukaryotic host cell comprising a non-ribosomal peptide synthetase and a polynucleotide allowing the expression of an MbtH-like protein.

AB - The present invention relates to a method to improve the production of a secondary metabolite catalyzed by a non-ribosomal peptide synthetase comprising contacting in a eukaryotic host a eukaryotic non-ribosomal peptide synthetase with an MbtH-like protein. The present invention further relates to a composition comprising a eukaryotic non-ribosomal peptide synthetase that is not a hybrid and a prokaryotic MbtH and to a eukaryotic host cell comprising a non-ribosomal peptide synthetase and a polynucleotide allowing the expression of an MbtH-like protein.

M3 - Patent

M1 - WO2017178624

ER -