Mbth-like proteins in eukaryotic nrps-catalyzed processes

Roelof Ary Lans Bovenberg (Inventor), Ulrike Maria Muller (Inventor), Arnold Jacob Mathieu Driessen (Inventor), Carsten Pohl (Inventor), Reto Daniel Zwahlen (Inventor)

Research output: Patent


The present invention relates to a method to improve the production of a secondary metabolite catalyzed by a non-ribosomal peptide synthetase comprising contacting in a eukaryotic host a eukaryotic non-ribosomal peptide synthetase with an MbtH-like protein. The present invention further relates to a composition comprising a eukaryotic non-ribosomal peptide synthetase that is not a hybrid and a prokaryotic MbtH and to a eukaryotic host cell comprising a non-ribosomal peptide synthetase and a polynucleotide allowing the expression of an MbtH-like protein.
Original languageEnglish
Patent numberWO2017178624
Priority date14/04/2016
Publication statusPublished - 19-Oct-2017


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