Mealtime insulin bolus adherence and glycemic control in adolescents on insulin pump therapy

Poor self-management contributes to insufficient glycemic control in adolescents with type 1 diabetes (T1DM). We assessed the effects on glycemic control of adherence to self-measurement of blood glucose (SMBG) and insulin boluses in 90 adolescents with T1DM on insulin pump therapy over a 2-month period. We compared the number of insulin boluses and SMBGs around main meals to the gold standard of optimal diabetes management (SMBGs and a bolus before each main meal and SMBG before bedtime). The mean (95% CI) HbA1c levels were 2.9(1.7 to 4.0)mmol/mol lower for every additional insulin bolus and 3.1(1.6 to 4.5)mmol/mol lower for every additional SMBG. Patients performing SMBG and bolusing around each main meal had considerably lower HbA1c levels than those unable to do (95% CI for difference 4.3 to 10.4mmol/mol and 11.5 to 20.1mmol/mol respectively). For each additional mealtime bolus/day, the odds ratio of achieving target HbA1c levels of