Mechanical Properties of Aligned Nanotopologies for Directing Cellular Behavior

Qihui Zhou; Patrick Wünnemann; Philipp T. Kuhn; Joop de Vries; Marta Helmin; Alexander Böker; Theo G. van Kooten; Patrick van Rijn

doi:10.1002/admi.201600275

Mechanical Properties of Aligned Nanotopologies for Directing Cellular Behavior

Qihui Zhou, Patrick Wünnemann, Philipp T. Kuhn, Joop de Vries, Marta Helmin, Alexander Böker, Theo G. van Kooten, Patrick van Rijn^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Tailoring cell–surface interactions is important for the of design medical implants as well as regenerative medicine and tissue engineering materials. Here the single parameter system is transcended via translating hard nanotopology into soft polymeric hydrogel structures via hydrogel imprinting lithography. The response of these cells to the nanotopology of the same dimensions but with different mechanical properties displays unexpected behavior between “hard” tissue cells and “soft” tissue cells.

Original language	English
Article number	1600275
Number of pages	10
Journal	Advanced Materials Interfaces
Volume	3
Issue number	18
DOIs	https://doi.org/10.1002/admi.201600275
Publication status	Published - 20-Sept-2016

Keywords

STEM-CELLS
DESIGNING MATERIALS
SOFT LITHOGRAPHY
SURFACE
DIFFERENTIATION
GRADIENTS
SUBSTRATE
ALIGNMENT
FATE
NANOSCALE

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title = "Mechanical Properties of Aligned Nanotopologies for Directing Cellular Behavior",

abstract = "Tailoring cell–surface interactions is important for the of design medical implants as well as regenerative medicine and tissue engineering materials. Here the single parameter system is transcended via translating hard nanotopology into soft polymeric hydrogel structures via hydrogel imprinting lithography. The response of these cells to the nanotopology of the same dimensions but with different mechanical properties displays unexpected behavior between “hard” tissue cells and “soft” tissue cells.",

keywords = "STEM-CELLS, DESIGNING MATERIALS, SOFT LITHOGRAPHY, SURFACE, DIFFERENTIATION, GRADIENTS, SUBSTRATE, ALIGNMENT, FATE, NANOSCALE",

author = "Qihui Zhou and Patrick W{\"u}nnemann and Kuhn, {Philipp T.} and {de Vries}, Joop and Marta Helmin and Alexander B{\"o}ker and {van Kooten}, {Theo G.} and {van Rijn}, Patrick",

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day = "20",

doi = "10.1002/admi.201600275",

language = "English",

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T1 - Mechanical Properties of Aligned Nanotopologies for Directing Cellular Behavior

AU - Zhou, Qihui

AU - Wünnemann, Patrick

AU - Kuhn, Philipp T.

AU - de Vries, Joop

AU - Helmin, Marta

AU - Böker, Alexander

AU - van Kooten, Theo G.

AU - van Rijn, Patrick

PY - 2016/9/20

Y1 - 2016/9/20

N2 - Tailoring cell–surface interactions is important for the of design medical implants as well as regenerative medicine and tissue engineering materials. Here the single parameter system is transcended via translating hard nanotopology into soft polymeric hydrogel structures via hydrogel imprinting lithography. The response of these cells to the nanotopology of the same dimensions but with different mechanical properties displays unexpected behavior between “hard” tissue cells and “soft” tissue cells.

AB - Tailoring cell–surface interactions is important for the of design medical implants as well as regenerative medicine and tissue engineering materials. Here the single parameter system is transcended via translating hard nanotopology into soft polymeric hydrogel structures via hydrogel imprinting lithography. The response of these cells to the nanotopology of the same dimensions but with different mechanical properties displays unexpected behavior between “hard” tissue cells and “soft” tissue cells.

KW - STEM-CELLS

KW - DESIGNING MATERIALS

KW - SOFT LITHOGRAPHY

KW - SURFACE

KW - DIFFERENTIATION

KW - GRADIENTS

KW - SUBSTRATE

KW - ALIGNMENT

KW - FATE

KW - NANOSCALE

U2 - 10.1002/admi.201600275

DO - 10.1002/admi.201600275

M3 - Article

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VL - 3

JO - Advanced Materials Interfaces

JF - Advanced Materials Interfaces

IS - 18

M1 - 1600275

ER -

Mechanical Properties of Aligned Nanotopologies for Directing Cellular Behavior

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Keywords

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