Mechanical Properties of Aligned Nanotopologies for Directing Cellular Behavior

Qihui Zhou, Patrick Wünnemann, Philipp T. Kuhn, Joop de Vries, Marta Helmin, Alexander Böker, Theo G. van Kooten, Patrick van Rijn*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

18 Citations (Scopus)

Abstract

Tailoring cell–surface interactions is important for the of design medical implants as well as regenerative medicine and tissue engineering materials. Here the single parameter system is transcended via translating hard nanotopology into soft polymeric hydrogel structures via hydrogel imprinting lithography. The response of these cells to the nanotopology of the same dimensions but with different mechanical properties displays unexpected behavior between “hard” tissue cells and “soft” tissue cells.
Original languageEnglish
Article number1600275
Number of pages10
JournalAdvanced Materials Interfaces
Volume3
Issue number18
DOIs
Publication statusPublished - 20-Sep-2016

Keywords

  • STEM-CELLS
  • DESIGNING MATERIALS
  • SOFT LITHOGRAPHY
  • SURFACE
  • DIFFERENTIATION
  • GRADIENTS
  • SUBSTRATE
  • ALIGNMENT
  • FATE
  • NANOSCALE

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