Mechanisms of cellular resistance to cisplatin

G. A. P. Hospers*, N. H. Mulder, E. G. E. de Vries

*Corresponding author for this work

    Research output: Contribution to journalReview articlepeer-review

    35 Citations (Scopus)

    Abstract

    Treatment of cancer patients often fails because of the resistance in the tumor to chemotherapeutic drugs. A better understanding of mechanisms which are active in resistant cells might lead to measures to circumvent the resistance. This review deals with the mechanisms of action of cisplatin (CDDP) and the various causes for CDDP resistance in the tumor cells. Also, possibilities to circumvent CDDP resistancein vitro andin vivo are presented.
    Original languageEnglish
    Pages (from-to)145-151
    Number of pages7
    JournalMedical oncology and tumor pharmacotherapy
    Volume5
    Issue number3
    DOIs
    Publication statusPublished - 1988

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