Mechanisms of cellular resistance to cisplatin

G. A. P. Hospers; N. H. Mulder; E. G. E. de Vries

doi:10.1007/BF02986437

Mechanisms of cellular resistance to cisplatin

G. A. P. Hospers^*, N. H. Mulder, E. G. E. de Vries

^*Corresponding author for this work

Guided Treatment in Optimal Selected Cancer Patients (GUTS)

Research output: Contribution to journal › Review article › Academic › peer-review

32 Citations (Scopus)

Abstract

Treatment of cancer patients often fails because of the resistance in the tumor to chemotherapeutic drugs. A better understanding of mechanisms which are active in resistant cells might lead to measures to circumvent the resistance. This review deals with the mechanisms of action of cisplatin (CDDP) and the various causes for CDDP resistance in the tumor cells. Also, possibilities to circumvent CDDP resistancein vitro andin vivo are presented.

Original language	English
Pages (from-to)	145-151
Number of pages	7
Journal	Medical oncology and tumor pharmacotherapy
Volume	5
Issue number	3
DOIs	https://doi.org/10.1007/BF02986437
Publication status	Published - 1988

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10.1007/BF02986437

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title = "Mechanisms of cellular resistance to cisplatin",

abstract = "Treatment of cancer patients often fails because of the resistance in the tumor to chemotherapeutic drugs. A better understanding of mechanisms which are active in resistant cells might lead to measures to circumvent the resistance. This review deals with the mechanisms of action of cisplatin (CDDP) and the various causes for CDDP resistance in the tumor cells. Also, possibilities to circumvent CDDP resistancein vitro andin vivo are presented.",

author = "Hospers, {G. A. P.} and Mulder, {N. H.} and {de Vries}, {E. G. E.}",

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T1 - Mechanisms of cellular resistance to cisplatin

AU - Hospers, G. A. P.

AU - Mulder, N. H.

AU - de Vries, E. G. E.

PY - 1988

Y1 - 1988

N2 - Treatment of cancer patients often fails because of the resistance in the tumor to chemotherapeutic drugs. A better understanding of mechanisms which are active in resistant cells might lead to measures to circumvent the resistance. This review deals with the mechanisms of action of cisplatin (CDDP) and the various causes for CDDP resistance in the tumor cells. Also, possibilities to circumvent CDDP resistancein vitro andin vivo are presented.

AB - Treatment of cancer patients often fails because of the resistance in the tumor to chemotherapeutic drugs. A better understanding of mechanisms which are active in resistant cells might lead to measures to circumvent the resistance. This review deals with the mechanisms of action of cisplatin (CDDP) and the various causes for CDDP resistance in the tumor cells. Also, possibilities to circumvent CDDP resistancein vitro andin vivo are presented.

U2 - 10.1007/BF02986437

DO - 10.1007/BF02986437

M3 - Review article

VL - 5

SP - 145

EP - 151

JO - Medical oncology and tumor pharmacotherapy

JF - Medical oncology and tumor pharmacotherapy

SN - 1559-131X

IS - 3

ER -