Mechanisms of cellular resistance to cisplatin

G. A. P. Hospers; N. H. Mulder; E. G. E. de Vries

doi:10.1007/BF02986437

Mechanisms of cellular resistance to cisplatin

G. A. P. Hospers^*, N. H. Mulder, E. G. E. de Vries

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

35 Citations (Scopus)

Abstract

Treatment of cancer patients often fails because of the resistance in the tumor to chemotherapeutic drugs. A better understanding of mechanisms which are active in resistant cells might lead to measures to circumvent the resistance. This review deals with the mechanisms of action of cisplatin (CDDP) and the various causes for CDDP resistance in the tumor cells. Also, possibilities to circumvent CDDP resistancein vitro andin vivo are presented.

Original language	English
Pages (from-to)	145-151
Number of pages	7
Journal	Medical oncology and tumor pharmacotherapy
Volume	5
Issue number	3
DOIs	https://doi.org/10.1007/BF02986437
Publication status	Published - 1988

Access to Document

10.1007/BF02986437

Handle.net

Persistent link

Cite this

@article{af9edb57cb164041960a1659531bbf44,

title = "Mechanisms of cellular resistance to cisplatin",

abstract = "Treatment of cancer patients often fails because of the resistance in the tumor to chemotherapeutic drugs. A better understanding of mechanisms which are active in resistant cells might lead to measures to circumvent the resistance. This review deals with the mechanisms of action of cisplatin (CDDP) and the various causes for CDDP resistance in the tumor cells. Also, possibilities to circumvent CDDP resistancein vitro andin vivo are presented.",

author = "Hospers, {G. A. P.} and Mulder, {N. H.} and {de Vries}, {E. G. E.}",

year = "1988",

doi = "10.1007/BF02986437",

language = "English",

volume = "5",

pages = "145--151",

journal = "Medical oncology and tumor pharmacotherapy",

number = "3",

}

TY - JOUR

T1 - Mechanisms of cellular resistance to cisplatin

AU - Hospers, G. A. P.

AU - Mulder, N. H.

AU - de Vries, E. G. E.

PY - 1988

Y1 - 1988

N2 - Treatment of cancer patients often fails because of the resistance in the tumor to chemotherapeutic drugs. A better understanding of mechanisms which are active in resistant cells might lead to measures to circumvent the resistance. This review deals with the mechanisms of action of cisplatin (CDDP) and the various causes for CDDP resistance in the tumor cells. Also, possibilities to circumvent CDDP resistancein vitro andin vivo are presented.

AB - Treatment of cancer patients often fails because of the resistance in the tumor to chemotherapeutic drugs. A better understanding of mechanisms which are active in resistant cells might lead to measures to circumvent the resistance. This review deals with the mechanisms of action of cisplatin (CDDP) and the various causes for CDDP resistance in the tumor cells. Also, possibilities to circumvent CDDP resistancein vitro andin vivo are presented.

U2 - 10.1007/BF02986437

DO - 10.1007/BF02986437

M3 - Review article

VL - 5

SP - 145

EP - 151

JO - Medical oncology and tumor pharmacotherapy

JF - Medical oncology and tumor pharmacotherapy

IS - 3

ER -

Mechanisms of cellular resistance to cisplatin

Abstract

Access to Document

Handle.net

Fingerprint

Cite this