Mechanisms of cellular resistance to cisplatin

G. A. P. Hospers*, N. H. Mulder, E. G. E. de Vries

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

35 Citations (Scopus)


Treatment of cancer patients often fails because of the resistance in the tumor to chemotherapeutic drugs. A better understanding of mechanisms which are active in resistant cells might lead to measures to circumvent the resistance. This review deals with the mechanisms of action of cisplatin (CDDP) and the various causes for CDDP resistance in the tumor cells. Also, possibilities to circumvent CDDP resistancein vitro andin vivo are presented.
Original languageEnglish
Pages (from-to)145-151
Number of pages7
JournalMedical oncology and tumor pharmacotherapy
Issue number3
Publication statusPublished - 1988

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