Mechanisms of enhanced thrombin generating capacity in patients with cirrhosis.

Johannes Lisman, Sarah Bos, Nicolas M. Intagliata

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Scopus)
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Abstract

The liver is the site of synthesis of many proteins involved in hemostasis including pro- and anticoagulant proteins, pro- and antifibrinolytic proteins, and thrombopoietin. Consequently, patients with liver disease acquire complex changes within their hemostatic system[1]. Historically, these changes were thought to result in a bleeding diathesis. Although bleeding complications are common in patients with chronic liver disease, the most common bleeding complication, variceal bleeding, is a consequence of portal hypertension, rather than hemostatic failure.
Original languageEnglish
Pages (from-to)1128-1131
Number of pages4
JournalJOURNAL OF THROMBOSIS AND HAEMOSTASIS
Volume16
Issue number6
DOIs
Publication statusPublished - Jun-2018

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