Mechanisms underlying elevated SBP differ with adiposity in young adults: the Enigma study

Jessica E. Middlemiss; Karen L. Miles; Barry J. McDonnell; null Yasmin; Kaisa M. Maki-Petaja; John R. Cockcroft; Ian B. Wilkinson; Carmel M. McEniery; Enigma Study Investigators

doi:10.1097/HJH.0000000000000798

Mechanisms underlying elevated SBP differ with adiposity in young adults: the Enigma study

Jessica E. Middlemiss^*, Karen L. Miles, Barry J. McDonnell, Yasmin, Kaisa M. Maki-Petaja, John R. Cockcroft, Ian B. Wilkinson, Carmel M. McEniery, Enigma Study Investigators

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Objectives:The positive association between adiposity and hypertension is well recognized. However, not all overweight individuals have elevated blood pressure (BP). Moreover, different factors may be associated with high BP in normal-weight versus overweight individuals. The aim of the current study was to examine the influence of adiposity on the relationship between SBP and underlying haemodynamic mechanisms in young adults.Method:Data from 2502 patients were available from the Enigma study. Detailed demographic, biochemical, and haemodynamic data were obtained in all individuals. Data were analysed between lower and upper tertiles of BMI and SBP, separately for each sex.Results:In normal-weight individuals, cardiac output (CO) was elevated in those with higher SBP, independently of body size. Moreover, higher CO was associated with an increased stroke volume in men (P

Original language	English
Pages (from-to)	290-297
Number of pages	8
Journal	Journal of Hypertension
Volume	34
Issue number	2
DOIs	https://doi.org/10.1097/HJH.0000000000000798
Publication status	Published - Feb-2016

Keywords

adiposity
BMI
cardiac output
peripheral vascular resistance
SBP
ISOLATED SYSTOLIC HYPERTENSION
AMBULATORY BLOOD-PRESSURE
OBESITY-INDUCED HYPERTENSION
GAS REBREATHING TECHNIQUE
BODY-MASS INDEX
CARDIAC-OUTPUT
BORDERLINE HYPERTENSION
NONINVASIVE MEASUREMENT
INTRAVASCULAR VOLUME
SCIENTIFIC STATEMENT

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Mechanisms underlying elevated SBP differ with adiposity in young adultsFinal publisher's version, 355 KBLicence: CC BY

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@article{426e5d3fe0704beea41967ea9fa35af3,

title = "Mechanisms underlying elevated SBP differ with adiposity in young adults: the Enigma study",

abstract = "Objectives:The positive association between adiposity and hypertension is well recognized. However, not all overweight individuals have elevated blood pressure (BP). Moreover, different factors may be associated with high BP in normal-weight versus overweight individuals. The aim of the current study was to examine the influence of adiposity on the relationship between SBP and underlying haemodynamic mechanisms in young adults.Method:Data from 2502 patients were available from the Enigma study. Detailed demographic, biochemical, and haemodynamic data were obtained in all individuals. Data were analysed between lower and upper tertiles of BMI and SBP, separately for each sex.Results:In normal-weight individuals, cardiac output (CO) was elevated in those with higher SBP, independently of body size. Moreover, higher CO was associated with an increased stroke volume in men (P",

keywords = "adiposity, BMI, cardiac output, peripheral vascular resistance, SBP, ISOLATED SYSTOLIC HYPERTENSION, AMBULATORY BLOOD-PRESSURE, OBESITY-INDUCED HYPERTENSION, GAS REBREATHING TECHNIQUE, BODY-MASS INDEX, CARDIAC-OUTPUT, BORDERLINE HYPERTENSION, NONINVASIVE MEASUREMENT, INTRAVASCULAR VOLUME, SCIENTIFIC STATEMENT",

author = "Middlemiss, {Jessica E.} and Miles, {Karen L.} and McDonnell, {Barry J.} and Yasmin and Maki-Petaja, {Kaisa M.} and Cockcroft, {John R.} and Wilkinson, {Ian B.} and McEniery, {Carmel M.} and {Enigma Study Investigators} and C.A. Hartman and Hoekstra, {Pieter J.} and {van Tol}, M.-J",

year = "2016",

month = feb,

doi = "10.1097/HJH.0000000000000798",

language = "English",

volume = "34",

pages = "290--297",

journal = "Journal of Hypertension",

issn = "0263-6352",

publisher = "Lippincott Williams and Wilkins",

number = "2",

}

TY - JOUR

T1 - Mechanisms underlying elevated SBP differ with adiposity in young adults

T2 - the Enigma study

AU - Middlemiss, Jessica E.

AU - Miles, Karen L.

AU - McDonnell, Barry J.

AU - Yasmin, null

AU - Maki-Petaja, Kaisa M.

AU - Cockcroft, John R.

AU - Wilkinson, Ian B.

AU - McEniery, Carmel M.

AU - Enigma Study Investigators

AU - Hartman, C.A.

AU - Hoekstra, Pieter J.

AU - van Tol, M.-J

PY - 2016/2

Y1 - 2016/2

N2 - Objectives:The positive association between adiposity and hypertension is well recognized. However, not all overweight individuals have elevated blood pressure (BP). Moreover, different factors may be associated with high BP in normal-weight versus overweight individuals. The aim of the current study was to examine the influence of adiposity on the relationship between SBP and underlying haemodynamic mechanisms in young adults.Method:Data from 2502 patients were available from the Enigma study. Detailed demographic, biochemical, and haemodynamic data were obtained in all individuals. Data were analysed between lower and upper tertiles of BMI and SBP, separately for each sex.Results:In normal-weight individuals, cardiac output (CO) was elevated in those with higher SBP, independently of body size. Moreover, higher CO was associated with an increased stroke volume in men (P

AB - Objectives:The positive association between adiposity and hypertension is well recognized. However, not all overweight individuals have elevated blood pressure (BP). Moreover, different factors may be associated with high BP in normal-weight versus overweight individuals. The aim of the current study was to examine the influence of adiposity on the relationship between SBP and underlying haemodynamic mechanisms in young adults.Method:Data from 2502 patients were available from the Enigma study. Detailed demographic, biochemical, and haemodynamic data were obtained in all individuals. Data were analysed between lower and upper tertiles of BMI and SBP, separately for each sex.Results:In normal-weight individuals, cardiac output (CO) was elevated in those with higher SBP, independently of body size. Moreover, higher CO was associated with an increased stroke volume in men (P

KW - adiposity

KW - BMI

KW - cardiac output

KW - peripheral vascular resistance

KW - SBP

KW - ISOLATED SYSTOLIC HYPERTENSION

KW - AMBULATORY BLOOD-PRESSURE

KW - OBESITY-INDUCED HYPERTENSION

KW - GAS REBREATHING TECHNIQUE

KW - BODY-MASS INDEX

KW - CARDIAC-OUTPUT

KW - BORDERLINE HYPERTENSION

KW - NONINVASIVE MEASUREMENT

KW - INTRAVASCULAR VOLUME

KW - SCIENTIFIC STATEMENT

U2 - 10.1097/HJH.0000000000000798

DO - 10.1097/HJH.0000000000000798

M3 - Article

SN - 0263-6352

VL - 34

SP - 290

EP - 297

JO - Journal of Hypertension

JF - Journal of Hypertension

IS - 2

ER -

Mechanisms underlying elevated SBP differ with adiposity in young adults: the Enigma study

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Keywords

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