Mediators in cardiovascular disease: association with Raynaud’s phenomenon

    Research output: ThesisThesis fully internal (DIV)

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    Raynaud’s phenomenon (RP), often the first presenting sign of SSc-related vasculopathy,
    is a frequently occurring disorder, and most studies in the general population reported
    a prevalence rate of 3%–5%. Generally, vasculopathy is known to significantly impair patients’
    quality of life. Although vascular injury may directly arise from different etiologies,
    addressing risk factors associated with vasculopathy development is essential because
    this enables prevention. Vasculopathy plays an important role in the pathophysiology of
    SSc, and it is believed to be caused by abnormal neovascularization and remodeling of
    the vessels. Although SSc-related vasculopathy is undoubtedly complex and only partially
    understood, oxidative stress has been implicated to play an important role in its initiation
    and progression.
    Despite considerable advances in the last decade,the inability to identify patients with Raynaud’s at increased risk of developing SSc remains a problem. Any therapy started later in the disease may only attenuate disease processes and symptoms without modifying the disease course and outcome. Although underlying systemic disease should be excluded in patients presenting with RP, other easily overlooked causes should be considered, such as low body weight or recent
    weight loss. This dissertation reveals these important factors as well as less traditional
    factors such as the role of oxidative stress. Additionally, the current thesis has provided
    valuable insight into the significance of free thiols in the general population.
    Original languageEnglish
    QualificationDoctor of Philosophy
    Awarding Institution
    • University of Groningen
    • van Goor, Harry, Supervisor
    • Gans, Rijk, Supervisor
    • Mulder, Udo, Co-supervisor
    Award date20-Dec-2021
    Place of Publication[Groningen]
    Publication statusPublished - 2021


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