Medicaments for the treatment of vasoconstriction related diseases or disorders

Robert Henk Henning (Inventor), Gerrit Jan Willem Euverink (Inventor), Guido Krenning (Inventor), Adrianus Cornelis van der Graaf (Inventor)

Research output: Patent

Abstract

The present invention relates to medicaments for use in the prophylaxis or treatment of vasoconstriction related disorders or conditions. Specifically, the present invention relates to (2R) enantiomeric form of a 6-chromanol derivative for use in the prophylactic or treatment of vasoconstriction related disorders or conditions. A preferred 6-chromanol derivative is (6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)(piperazin-l-yl)methanone; N-(benzyl)-6-hydroxy- 2,5,7, 8-tetramethylchroman-2-carboxamide; N-(phenyl)-6-hydroxy-2,5,7,8-tetramethylchroman-2- carboxamide; methyl 4-(6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxamido)benzoate; (6- hydroxy-2,5,7,8-tetramethylchroman-2-yl)(morpholino)methanone, and pharmaceutically acceptable salts thereof.
Original languageEnglish
Patent numberWO2019038361
Priority date25/08/2017
Filing date23/02/2018
Publication statusPublished - 28-Feb-2019

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