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Abstract

Three amino-acid loop extension (TALE) homeobox proteins MEIS and PBX are cofactors for HOX-class homeobox proteins, which control growth and differentiation during embryogenesis and homeostasis. We showed that MEIS and PBX expression are related to cisplatin resistance in ovarian cancer cell lines. Therefore, MEIS1, MEIS2 and PBX expression were investigated immunohistochemically in a tissue microarray (N = 232) of ovarian cancers and ovarian surface epithelium (N = 15). Results were related to clinicopathologic characteristics and survival. All cancers expressed MEIS1, MEIS2 and PBX in nucleus and cytoplasm. MEIS1 and 2 only stained nuclear in surface epithelium. Nuclear MEIS2 was negatively related to stage, grade and overall survival in univariate analyses. Additionally, MEIS and PBX RNA expression in ovarian surface epithelium and other normal tissues and ovarian cancer versus other tumour types using public array data sets were studied. In ovarian cancer, MEIS1 is highly expressed compared to other cancer types. In conclusion, MEIS and PBX are extensively expressed in ovarian carcinomas and may play a role in ovarian carcinogenesis. (c) 2007 Elsevier Ltd. All rights reserved

Original languageEnglish
Pages (from-to)2495-2505
Number of pages11
JournalEuropean Journal of Cancer
Volume43
Issue number17
DOIs
Publication statusPublished - Nov-2007

Keywords

  • ovarian cancer
  • immunohistochemistry
  • tissue microarray
  • homeobox proteins
  • MEIS
  • PBX
  • GENE-EXPRESSION PROFILES
  • HOX GENES
  • DNA-BINDING
  • EPITHELIAL-CELLS
  • P53 EXPRESSION
  • NCBI GEO
  • APOPTOSIS
  • IDENTIFICATION
  • TRANSLOCATION
  • MILLIONS

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