Melanopsin- and L-cone-induced pupil constriction is inhibited by S- and M-cones in humans

Tom Woelders*, Thomas Leenheers, Marijke C. M. Gordijn, Roelof A. Hut, Domien G. M. Beersma, Emma J. Wams

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

43 Citations (Scopus)
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Abstract

The human retina contains five photoreceptor types: rods; short (S)-, mid (M)-, and long (L)-wavelength-sensitive cones; and melanopsin-expressing ganglion cells. Recently, it has been shown that selective increments in M-cone activation are paradoxically perceived as brightness decrements, as opposed to L-cone increments. Here we show that similar effects are also observed in the pupillary light response, whereby M-cone or S-cone increments lead to pupil dilation whereas L-cone or melanopic illuminance increments resulted in pupil constriction. Additionally, intermittent photoreceptor activation increased pupil constriction over a 30-min interval. Modulation of L-cone or melanopic illuminance within the 0.25-4-Hz frequency range resulted in more sustained pupillary constriction than light of constant intensity. Opposite results were found for S-cone and M-cone modulations (2 Hz), mirroring the dichotomy observed in the transient responses. The transient and sustained pupillary light responses therefore suggest that S-and M-cones provide inhibitory input to the pupillary control system when selectively activated, whereas L-cones and melanopsin response fulfill an excitatory role. These findings provide insight into functional networks in the human retina and the effect of color-coding in nonvisual responses to light, and imply that nonvisual and visual brightness discrimination may share a common pathway that starts in the retina.

Original languageEnglish
Pages (from-to)792-797
Number of pages6
JournalProceedings of the National Academy of Science of the United States of America
Volume115
Issue number4
DOIs
Publication statusPublished - 23-Jan-2018

Keywords

  • human pupillary light response
  • silent substitution
  • cones
  • melanopsin
  • ipRGC
  • RETINAL GANGLION-CELLS
  • STIMULATION
  • LIGHT
  • PHOTORECEPTORS
  • RESPONSES
  • LUMINANCE
  • PATHWAYS
  • PRIMATE
  • COLOR

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