Membrane-bound organelles versus membrane-less compartments and their control of anabolic pathways in Drosophila

Angelica Aguilera-Gomez, Catherine Rabouille*

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

    27 Citations (Scopus)
    365 Downloads (Pure)

    Abstract

    Classically, we think of cell compartmentalization as being achieved by membrane-bound organelles. It has nevertheless emerged that membrane-less assemblies also largely contribute to this compartmentalization. Here, we compare the characteristics of both types of compartmentalization in term of maintenance of functional identities. Furthermore, membrane less-compartments are critical for sustaining developmental and cell biological events as they control major metabolic pathways. We describe two examples related to this issue in Drosophila, the role of P-bodies in the translational control of gurken in the Drosophila oocyte, and the formation of Sec bodies upon amino-acid starvation in Drosophila cells.

    Original languageEnglish
    Pages (from-to)310-317
    Number of pages8
    JournalDevelopmental Biology
    Volume428
    Issue number2
    DOIs
    Publication statusPublished - 15-Aug-2017

    Keywords

    • Cell compartmentalization
    • Membrane-bound organelles
    • Membrane-less compartments
    • Liquid droplets
    • Liquid-liquid phase separation
    • Low complexity sequence
    • Secretory pathway
    • ER exit sites
    • gurken translation
    • Drosophila
    • Oocyte
    • Orb
    • S2 cells
    • COPII
    • Sec16
    • PARP16
    • Stress granule
    • mRNA
    • FMR1
    • GURKEN MESSENGER-RNA
    • CELL-FREE FORMATION
    • STRESS GRANULES
    • PHASE-SEPARATION
    • P-BODIES
    • COPII COAT
    • SECRETORY PATHWAY
    • ENDOPLASMIC-RETICULUM
    • AXIS DETERMINATION
    • PROCESSING BODIES

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