Membrane Contact Sites in Autophagy

Emma Zwilling, Fulvio Reggiori

Research output: Contribution to journalReview articlepeer-review

3 Citations (Scopus)
49 Downloads (Pure)

Abstract

Eukaryotes utilize different communication strategies to coordinate processes between different cellular compartments either indirectly, through vesicular transport, or directly, via membrane contact sites (MCSs). MCSs have been implicated in lipid metabolism, calcium signaling and the regulation of organelle biogenesis in various cell types. Several studies have shown that MCSs play a crucial role in the regulation of macroautophagy, an intracellular catabolic transport route that is characterized by the delivery of cargoes (proteins, protein complexes or aggregates, organelles and pathogens) to yeast and plant vacuoles or mammalian lysosomes, for their degradation and recycling into basic metabolites. Macroautophagy is characterized by the de novo formation of double-membrane vesicles called autophagosomes, and their biogenesis requires an enormous amount of lipids. MCSs appear to have a central role in this supply, as well as in the organization of the autophagy-related (ATG) machinery. In this review, we will summarize the evidence for the participation of specific MCSs in autophagosome formation, with a focus on the budding yeast and mammalian systems.

Original languageEnglish
Article number3813
Number of pages16
JournalCells
Volume11
Issue number23
DOIs
Publication statusPublished - 28-Nov-2022
Externally publishedYes

Keywords

  • Animals
  • Endoplasmic Reticulum/metabolism
  • Autophagosomes/metabolism
  • Autophagy
  • Lysosomes/metabolism
  • Saccharomyces cerevisiae/metabolism
  • Mammals

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