(Membrane) Protein Production in Context

Paul E. Schavemaker, Bert Poolman*

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

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Abstract

Great progress has been made in elucidating the structural and mechanistic basis of (membrane) protein production. Here, we attempt to look ahead and indicate four directions in which our understanding of the protein production process can grow: (i) determine how the molecular mechanisms influence higher-level processes, such as the distribution of protein copy number over a population of cells or the cell growth rate; (ii) explore the functional landscape that the molecular mechanisms of protein production exist in, for instance by comparing membrane protein insertion mechanisms; (iii) uncover the life history of proteins - that is, what happens to them between their synthesis and degradation; and (iv) determine, and connect by calculation, the numbers that are associated with (membrane) protein production.
Original languageEnglish
Pages (from-to)858-868
Number of pages11
JournalTrends in Biochemical Sciences
Volume43
Issue number11
Early online date13-Sep-2018
DOIs
Publication statusPublished - Nov-2018

Keywords

  • SINGLE-MOLECULE
  • STRUCTURAL BASIS
  • RNA-POLYMERASE
  • TRANSLATION
  • DATABASE
  • MECHANISM
  • RIBOSOMES

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