Membrane supply and remodeling during autophagosome biogenesis

Rubén Gómez-Sánchez, Sharon A Tooze, Fulvio Reggiori*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

49 Citations (Scopus)
68 Downloads (Pure)

Abstract

The de novo generation of double-membrane autophagosomes is the hallmark of autophagy. The initial membranous precursor cisterna, the phagophore, is very likely generated by the fusion of vesicles and acts as a membrane seed for the subsequent expansion into an autophagosome. This latter step requires a massive convoy of lipids into the phagophore. In this review, we present recent advances in our understanding of the intracellular membrane sources and lipid delivery mechanisms, which principally rely on vesicular transport and membrane contact sites that contribute to autophagosome biogenesis. In this context, we discuss lipid biosynthesis and lipid remodeling events that play a crucial role in both phagophore nucleation and expansion.

Original languageEnglish
Pages (from-to)112-119
Number of pages8
JournalCurrent Opinion in Cell Biology
Volume71
Early online date27-Apr-2021
DOIs
Publication statusPublished - Aug-2021

Keywords

  • Autophagy
  • Phagophore
  • Isolation membrane
  • Lipids
  • Membrane origin
  • Lipid source
  • Membrane contact site
  • Vesicular transport
  • Omegasome
  • ATG proteins
  • ER-EXIT SITES
  • ENDOPLASMIC-RETICULUM
  • CONTACT SITES
  • ATG9 VESICLES
  • EARLY STEPS
  • PROTEINS
  • PHAGOPHORE
  • REVEALS
  • COMPARTMENT
  • CONTRIBUTE

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