Men Versus Women on Sexual Brain Function: Prominent Differences During Tactile Genital Stimulation, but not During Orgasm

Janniko R. Georgiadis*, A. A. T. Simone Reinders, Anne M. J. Paans, Remco Renken, Rudie Kortekaas

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

71 Citations (Scopus)

Abstract

Biological differences in male and female sexuality are obvious in the behavioral domain, but the central mechanisms that might explain these behavioral gender differences remain unclear. In this study, we merged two earlier positron emission tomography data sets to enable systematic comparison of the brain responses in heterosexual men and women during sexual tactile genital (penile and clitoral) stimulation and during orgasm. Gender commonalities were most evident during orgasm, a phase which demonstrated activations in the anterior lobe of the cerebellar vermis and deep cerebellar nuclei, and deactivations in the left ventromedial and orbitofrontal cortex in both men and women. During tactile genital stimulation, deactivations in the right amygdala and left fusiform gyrus were found for both genders. Marked gender differences were seen during this phase: left fronto-parietal areas (motor cortices, somatosensory area 2 and posterior parietal cortex) were activated more in women, whereas in men, the right claustrum and ventral occipitotemporal cortex showed larger activation. The only prominent gender difference during orgasm was male-biased activation of the periaqueductal gray matter. From these results, we conclude that during the sexual act, differential brain responses across genders are principally related to the stimulatory (plateau) phase and not to the orgasmic phase itself. These results add to a better understanding of the neural underpinnings of human sexuality, which might benefit treatment of psychosexual disorders. Hum Brain Mapp 30:3089-3101, 2009. (C) 2009 Wiley-Liss, Inc.

Original languageEnglish
Pages (from-to)3089-3101
Number of pages13
JournalHuman brain mapping
Volume30
Issue number10
DOIs
Publication statusPublished - Oct-2009

Keywords

  • gender
  • orgasm
  • genitalia
  • PET
  • HUMAN ORBITOFRONTAL CORTEX
  • FEMALE REPRODUCTIVE-BEHAVIOR
  • MEDIAL PREFRONTAL CORTEX
  • HUMAN MALE EJACULATION
  • CEREBRAL-BLOOD-FLOW
  • FOS-IMMUNOREACTIVITY
  • PSEUDORABIES VIRUS
  • EXTENDED AMYGDALA
  • TALAIRACH ATLAS
  • FILM EXCERPTS

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