Mesenchymal Stem Cells Contribute to Tumor Cell Proliferation by Direct Cell-Cell Contact Interactions

Berber D. Roorda, Arja ter Elst, Tiny G. J. Meeuwsen-de Boer, Willem A. Kamps, Eveline S. J. M. de Bont*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

34 Citations (Scopus)

Abstract

Bone marrow (BM)-derived mesenchymal stem cells (MSCs) have been implicated in tumor progression, making MSCs important targets for anti-cancer strategies. In this study, we show that MSCs promote tumor growth in vivo in a lymphoma xenograft model. We show that MSCs provide direct cell-cell contact interactions and, to a lesser extend, soluble factors that promote tumor cell proliferation and survival in vitro. PTK787/ZK 222584 reduces tumor growth-promoting effects of MSCs both in vitro and in vivo. Our results address the importance of targeting the MSCs for future anti-cancer strategies.

Original languageEnglish
Pages (from-to)526-534
Number of pages9
JournalCancer Investigation
Volume28
Issue number5
DOIs
Publication statusPublished - Jun-2010

Keywords

  • Mesenchymal stem cells
  • Tumor growth
  • Angiogenesis
  • Vessel density
  • Proliferation
  • Apoptosis
  • PTK787/ZK 222584
  • MARROW STROMAL CELLS
  • VERSUS-HOST-DISEASE
  • GROWTH-FACTOR
  • VIVO
  • DIFFERENTIATE
  • APOPTOSIS
  • LYMPHOMA
  • LINES

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