Meta-analyses on suspected chronic obstructive pulmonary disease genes: a summary of 20 years' research

Joanna Smolonska, Cisca Wijmenga, Dirkje S. Postma, H. Marike Boezen*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

116 Citations (Scopus)

Abstract

Rationale: Chronic obstructive pulmonary disease (COPD) is a complex disorder with high mortality worldwide. Studies on the role of candidate genes and their polymorphisms in COPD development have so far produced ambiguous results.

Objectives: The aim of this study was to reveal the role of COPD candidate genes using data collected in previous research.

Methods: We performed meta-analyses on 20 polymorphisms in 12 genes, after searching the PubMed and Embase databases for publications on COPD. These genes involve three main pathways associated with COPD development: the inflammatory, protease-antiprotease balance, and antioxidant pathways.

Measurements and Main Results: We obtained significant results for three TGFB1 polymorphisms, although these were based only on a few studies. The IL1RN VNTR polymorphism increases the risk for COPD (odds ratio [OR], 1.7; 95% confidence interval [CI], 1.09-2.65), whereas the TNFA -308 G/A polymorphism does so only in Asian populations (OR, 2.01; 95% CI, 1.21-3.31). The GSTP1 I105V polymorphism was protective for COPD in Asian populations only (OR, 0.69; 95% Cl, 0.56-0.85).

Conclusions: These results demonstrate the importance of ethnicity in identifying specific COPD genes.

Original languageEnglish
Pages (from-to)618-631
Number of pages14
JournalAmerican Journal of Respiratory and Critical Care Medicine
Volume180
Issue number7
DOIs
Publication statusPublished - 1-Oct-2009

Keywords

  • chronic obstructive pulmonary disease
  • genes
  • polymorphism
  • single nucleotide polymorphisms
  • meta-analysis
  • ethnicity
  • MICROSOMAL EPOXIDE HYDROLASE
  • TUMOR-NECROSIS-FACTOR
  • GLUTATHIONE-S-TRANSFERASE
  • IL-1 RECEPTOR ANTAGONIST
  • LUNG-FUNCTION DECLINE
  • AIR-FLOW OBSTRUCTION
  • FACTOR-ALPHA
  • PROMOTER POLYMORPHISM
  • TNF-ALPHA
  • ALPHA(1)-ANTITRYPSIN DEFICIENCY

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