Meta-analysis of clinical characteristics of 299 carriers of LMNA gene mutations: do lamin A/C mutations portend a high risk of sudden death?

WG de Voogt, AJ van der Kooi, JP van Tintelen, G Bonne, R Ben Yaou, D Duboc, T Rossenbacker, H Heidbuchel, M de Visser, HJGM Crijns, YM Pinto*, Jop H. van Berlo

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

352 Citations (Scopus)

Abstract

This study evaluated common clinical characteristics of patients with lamin A/C gene mutations that cause either isolated dilated cardiornyopathy or dilated cardiomyopathy in association with skeletal muscular dystrophy. We pooled clinical data of all published carriers of lamin A/C gene mutations as cause of skeletal and/or cardiac muscle disease and reviewed ECG findings. Cardiac dysrhythmias were reported in 92% of patients after the age of 30 years; heart failure was reported in 64% after the age of 50. Sudden death was the most frequently reported mode of death (46%) in both the cardiac and the neuromuscular phenotype. Carriers of lamin A/C gene mutations often received a pacemaker (28%). However, this intervention did not alter the rate of sudden death. Review of the ECG findings typically showed a low amplitude P wave and prolongation of the PR interval with a narrow QRS complex. This meta-analysis suggests that cardiomyopathy due to lamin A/C gene mutations portends a high risk of sudden death, and that this risk does not differ between subjects with predominantly cardiac or neuromuscular disease. This implies then that all carriers of a lamin A/C gene mutation need to be carefully screened with particular emphasis also on tachyarrhythmias. Prospective studies are needed to evaluate risk stratification and proper treatment strategies.

Original languageEnglish
Pages (from-to)79-83
Number of pages5
JournalJournal of Molecular Medicine
Volume83
Issue number1
DOIs
Publication statusPublished - Jan-2005

Keywords

  • sudden death
  • cardiomyopathy
  • skeletal muscles
  • genetics
  • DREIFUSS MUSCULAR-DYSTROPHY
  • INTERMEDIATE FILAMENT PROTEINS
  • SKELETAL-MUSCLE INVOLVEMENT
  • CONDUCTION-SYSTEM DISEASE
  • CAUSE AUTOSOMAL-DOMINANT
  • DILATED CARDIOMYOPATHY
  • ATRIOVENTRICULAR-BLOCK
  • NUCLEAR-ENVELOPE
  • ROD DOMAIN
  • IDENTIFICATION

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