Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight

Leanne K. Kupers; Claire Monnereau; Gemma C. Sharp; Paul Yousefi; Lucas A. Salas; Akram Ghantous; Christian M. Page; Sarah E. Reese; Allen J. Wilcox; Darina Czamara; Anne P. Starling; Alexei Novoloaca; Samantha Lent; Ritu Roy; Cathrine Hoyo; Carrie Breton; Catherine Allard; Allan C. Just; Kelly M. Bakulski; John W. Holloway; Todd M. Everson; Cheng-Jian Xu; Rae-Chi Huang; Diana A. van der Plaat; Matthias Wielscher; Simon Kebede Merid; Vilhelmina Ullemar; Faisal Rezwan; Jari Lahti; Jenny van Dongen; Sabine A. S. Langie; Tom G. Richardson; Maria C. Magnus; Ellen A. Nohr; Zongli Xu; Liesbeth Duijts; Shanshan Zhao; Weiming Zhang; Michelle Plusquin; Dawn L. DeMeo; Olivia Solomon; Joosje H. Heimovaara; Dereje D. Jima; Lu Gao; Mariona Bustamante; Patrice Perron; Robert O. Wright; Irva Hertz-Picciotto; Hongmei Zhang; Margaret R. Karagas; Ulrike Gehring; Carmen J. Marsit; Lawrence J. Beilin; Judith M. Vonk; Marjo-Riitta Jarvelin; Anna Bergstrom; Anne K. Ortqvist; Susan Ewart; Pia M. Villa; Sophie E. Moore; Gonneke Willemsen; Arnout R. L. Standaert; Siri E. Haberg; Thorkild I. A. Sorensen; Jack A. Taylor; Katri Raikkonen; Ivana Yang; Katerina Kechris; Tim S. Nawrot; Matt J. Silver; Yun Yun Gong; Lorenzo Richiardi; Manolis Kogevinas; Augusto A. Litonjua; Brenda Eskenazi; Karen Huen; Hamdi Mbarek; Rachel L. Maguire; Terence Dwyer; Martine Vrijheid; Luigi Bouchard; Andrea A. Baccarelli; Lisa A. Croen; Wilfried Karmaus; Denise Anderson; Maaike de Vries; Sylvain Sebert; Juha Kere; Robert Karlsson; Syed Hasan Arshad; Esa Hamalainen; Michael N. Routledge; Dorret Boomsma; Andrew P. Feinberg; Craig J. Newschaffer; Eva Govarts; Matthieu Moisse; M. Daniele Fallin; Erik Melen; Andrew M. Prentice; Eero Kajantie; Catarina Almqvist; Emily Oken; Dana Dabelea; H. Marike Boezen; Phillip E. Melton; Rosalind J. Wright; Gerard H. Koppelman; Letizia Trevisi; Marie-France Hivert; Jordi Sunyer; Monica C. Munthe-Kaas; Susan K. Murphy; Eva Corpeleijn; Joseph Wiemels; Nina Holland; Zdenko Herceg; Elisabeth B. Binder; George Davey Smith; Vincent W. V. Jaddoe; Rolv T. Lie; Wenche Nystad; Stephanie J. London; Debbie A. Lawlor; Caroline L. Relton; Harold Snieder; Janine F. Felix

doi:10.1038/s41467-019-09671-3

Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight

Leanne K. Kupers, Claire Monnereau, Gemma C. Sharp, Paul Yousefi, Lucas A. Salas, Akram Ghantous, Christian M. Page, Sarah E. Reese, Allen J. Wilcox, Darina Czamara, Anne P. Starling, Alexei Novoloaca, Samantha Lent, Ritu Roy, Cathrine Hoyo, Carrie Breton, Catherine Allard, Allan C. Just, Kelly M. Bakulski, John W. HollowayTodd M. Everson, Cheng-Jian Xu, Rae-Chi Huang, Diana A. van der Plaat, Matthias Wielscher, Simon Kebede Merid, Vilhelmina Ullemar, Faisal Rezwan, Jari Lahti, Jenny van Dongen, Sabine A. S. Langie, Tom G. Richardson, Maria C. Magnus, Ellen A. Nohr, Zongli Xu, Liesbeth Duijts, Shanshan Zhao, Weiming Zhang, Michelle Plusquin, Dawn L. DeMeo, Olivia Solomon, Joosje H. Heimovaara, Dereje D. Jima, Lu Gao, Mariona Bustamante, Patrice Perron, Robert O. Wright, Irva Hertz-Picciotto, Hongmei Zhang, Margaret R. Karagas, Ulrike Gehring, Carmen J. Marsit, Lawrence J. Beilin, Judith M. Vonk, Marjo-Riitta Jarvelin, Anna Bergstrom, Anne K. Ortqvist, Susan Ewart, Pia M. Villa, Sophie E. Moore, Gonneke Willemsen, Arnout R. L. Standaert, Siri E. Haberg, Thorkild I. A. Sorensen, Jack A. Taylor, Katri Raikkonen, Ivana Yang, Katerina Kechris, Tim S. Nawrot, Matt J. Silver, Yun Yun Gong, Lorenzo Richiardi, Manolis Kogevinas, Augusto A. Litonjua, Brenda Eskenazi, Karen Huen, Hamdi Mbarek, Rachel L. Maguire, Terence Dwyer, Martine Vrijheid, Luigi Bouchard, Andrea A. Baccarelli, Lisa A. Croen, Wilfried Karmaus, Denise Anderson, Maaike de Vries, Sylvain Sebert, Juha Kere, Robert Karlsson, Syed Hasan Arshad, Esa Hamalainen, Michael N. Routledge, Dorret Boomsma, Andrew P. Feinberg, Craig J. Newschaffer, Eva Govarts, Matthieu Moisse, M. Daniele Fallin, Erik Melen, Andrew M. Prentice, Eero Kajantie, Catarina Almqvist, Emily Oken, Dana Dabelea, H. Marike Boezen, Phillip E. Melton, Rosalind J. Wright, Gerard H. Koppelman, Letizia Trevisi, Marie-France Hivert, Jordi Sunyer, Monica C. Munthe-Kaas, Susan K. Murphy, Eva Corpeleijn, Joseph Wiemels, Nina Holland, Zdenko Herceg, Elisabeth B. Binder, George Davey Smith, Vincent W. V. Jaddoe, Rolv T. Lie, Wenche Nystad, Stephanie J. London, Debbie A. Lawlor, Caroline L. Relton, Harold Snieder, Janine F. Felix

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Abstract

Birthweight is associated with health outcomes across the life course, DNA methylation may be an underlying mechanism. In this meta-analysis of epigenome-wide association studies of 8,825 neonates from 24 birth cohorts in the Pregnancy And Childhood Epigenetics Consortium, we find that DNA methylation in neonatal blood is associated with birthweight at 914 sites, with a difference in birthweight ranging from -183 to 178 grams per 10% increase in methylation (PBonferroni < 1.06 x 10-7). In additional analyses in 7,278 participants, <1.3% of birthweight-associated differential methylation is also observed in childhood and adolescence, but not adulthood. Birthweight-related CpGs overlap with some Bonferroni-significant CpGs that were previously reported to be related to maternal smoking (55/914, p = 6.12 x 10-74) and BMI in pregnancy (3/914, p = 1.13x10-3), but not with those related to folate levels in pregnancy. Whether the associations that we observe are causal or explained by confounding or fetal growth influencing DNA methylation (i.e. reverse causality) requires further research.

Original language	English
Article number	1893
Number of pages	11
Journal	Nature Communications
Volume	10
Issue number	1
DOIs	https://doi.org/10.1038/s41467-019-09671-3
Publication status	Published - 23-Apr-2019

Keywords

MENDELIAN RANDOMIZATION
MATERNAL SMOKING
FETAL ORIGINS
CORD BLOOD
EPIGENETIC MEDIATION
GENETIC-EVIDENCE
PREGNANCY
PACKAGE
DISEASE
BIOCONDUCTOR

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10.1038/s41467-019-09671-3Licence: CC BY

Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweightFinal publisher's version, 12.5 MBLicence: CC BY

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Dataset: Meta-analysis results of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight
Küpers, L. (Creator), University of Groningen, 12-Dec-2018
DOI: 10.5281/zenodo.2222287
Dataset
Additional file 7 of Developmental programming in human umbilical cord vein endothelial cells following fetal growth restriction
Terstappen, F. (Creator), Calis, J. J. A. (Creator), Paauw, N. D. (Creator), Joles, J. A. (Creator), van Rijn, B. B. (Contributor), Mokry, M. (Creator), Plösch, T. (Creator) & Lely, A. T. (Contributor), figshare, 30-Nov-2020
DOI: 10.6084/m9.figshare.13310377, https://springernature.figshare.com/articles/dataset/Additional_file_7_of_Developmental_programming_in_human_umbilical_cord_vein_endothelial_cells_following_fetal_growth_restriction/13310377
Dataset
GECKO Drenthe cohort
Corpeleijn, E. (Creator), Snieder, H. (Creator), Bocca, G. (Creator), Gracchi, V. (Creator) & Hoek, A. (Creator), University of Groningen, 2006
DOI: 10.34760/5f5b80eb0830f, http://www.geckodrenthe.umcg.nl and 2 more links, http://www.birthcohorts.net/birthcohorts/birthcohort/?id=138, https://umcgresearch.org/-/gecko (show fewer)
Dataset

Cite this

Kupers, L. K., Monnereau, C., Sharp, G. C., Yousefi, P., Salas, L. A., Ghantous, A., Page, C. M., Reese, S. E., Wilcox, A. J., Czamara, D., Starling, A. P., Novoloaca, A., Lent, S., Roy, R., Hoyo, C., Breton, C., Allard, C., Just, A. C., Bakulski, K. M., ... Felix, J. F. (2019). Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight. Nature Communications, 10(1), Article 1893. https://doi.org/10.1038/s41467-019-09671-3

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title = "Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight",

abstract = "Birthweight is associated with health outcomes across the life course, DNA methylation may be an underlying mechanism. In this meta-analysis of epigenome-wide association studies of 8,825 neonates from 24 birth cohorts in the Pregnancy And Childhood Epigenetics Consortium, we find that DNA methylation in neonatal blood is associated with birthweight at 914 sites, with a difference in birthweight ranging from -183 to 178 grams per 10% increase in methylation (PBonferroni < 1.06 x 10-7). In additional analyses in 7,278 participants, <1.3% of birthweight-associated differential methylation is also observed in childhood and adolescence, but not adulthood. Birthweight-related CpGs overlap with some Bonferroni-significant CpGs that were previously reported to be related to maternal smoking (55/914, p = 6.12 x 10-74) and BMI in pregnancy (3/914, p = 1.13x10-3), but not with those related to folate levels in pregnancy. Whether the associations that we observe are causal or explained by confounding or fetal growth influencing DNA methylation (i.e. reverse causality) requires further research.",

keywords = "MENDELIAN RANDOMIZATION, MATERNAL SMOKING, FETAL ORIGINS, CORD BLOOD, EPIGENETIC MEDIATION, GENETIC-EVIDENCE, PREGNANCY, PACKAGE, DISEASE, BIOCONDUCTOR",

author = "Kupers, {Leanne K.} and Claire Monnereau and Sharp, {Gemma C.} and Paul Yousefi and Salas, {Lucas A.} and Akram Ghantous and Page, {Christian M.} and Reese, {Sarah E.} and Wilcox, {Allen J.} and Darina Czamara and Starling, {Anne P.} and Alexei Novoloaca and Samantha Lent and Ritu Roy and Cathrine Hoyo and Carrie Breton and Catherine Allard and Just, {Allan C.} and Bakulski, {Kelly M.} and Holloway, {John W.} and Everson, {Todd M.} and Cheng-Jian Xu and Rae-Chi Huang and {van der Plaat}, {Diana A.} and Matthias Wielscher and Merid, {Simon Kebede} and Vilhelmina Ullemar and Faisal Rezwan and Jari Lahti and {van Dongen}, Jenny and Langie, {Sabine A. S.} and Richardson, {Tom G.} and Magnus, {Maria C.} and Nohr, {Ellen A.} and Zongli Xu and Liesbeth Duijts and Shanshan Zhao and Weiming Zhang and Michelle Plusquin and DeMeo, {Dawn L.} and Olivia Solomon and Heimovaara, {Joosje H.} and Jima, {Dereje D.} and Lu Gao and Mariona Bustamante and Patrice Perron and Wright, {Robert O.} and Irva Hertz-Picciotto and Hongmei Zhang and Karagas, {Margaret R.} and Ulrike Gehring and Marsit, {Carmen J.} and Beilin, {Lawrence J.} and Vonk, {Judith M.} and Marjo-Riitta Jarvelin and Anna Bergstrom and Ortqvist, {Anne K.} and Susan Ewart and Villa, {Pia M.} and Moore, {Sophie E.} and Gonneke Willemsen and Standaert, {Arnout R. L.} and Haberg, {Siri E.} and Sorensen, {Thorkild I. A.} and Taylor, {Jack A.} and Katri Raikkonen and Ivana Yang and Katerina Kechris and Nawrot, {Tim S.} and Silver, {Matt J.} and Gong, {Yun Yun} and Lorenzo Richiardi and Manolis Kogevinas and Litonjua, {Augusto A.} and Brenda Eskenazi and Karen Huen and Hamdi Mbarek and Maguire, {Rachel L.} and Terence Dwyer and Martine Vrijheid and Luigi Bouchard and Baccarelli, {Andrea A.} and Croen, {Lisa A.} and Wilfried Karmaus and Denise Anderson and {de Vries}, Maaike and Sylvain Sebert and Juha Kere and Robert Karlsson and Arshad, {Syed Hasan} and Esa Hamalainen and Routledge, {Michael N.} and Dorret Boomsma and Feinberg, {Andrew P.} and Newschaffer, {Craig J.} and Eva Govarts and Matthieu Moisse and Fallin, {M. Daniele} and Erik Melen and Prentice, {Andrew M.} and Eero Kajantie and Catarina Almqvist and Emily Oken and Dana Dabelea and Boezen, {H. Marike} and Melton, {Phillip E.} and Wright, {Rosalind J.} and Koppelman, {Gerard H.} and Letizia Trevisi and Marie-France Hivert and Jordi Sunyer and Munthe-Kaas, {Monica C.} and Murphy, {Susan K.} and Eva Corpeleijn and Joseph Wiemels and Nina Holland and Zdenko Herceg and Binder, {Elisabeth B.} and Smith, {George Davey} and Jaddoe, {Vincent W. V.} and Lie, {Rolv T.} and Wenche Nystad and London, {Stephanie J.} and Lawlor, {Debbie A.} and Relton, {Caroline L.} and Harold Snieder and Felix, {Janine F.}",

year = "2019",

month = apr,

day = "23",

doi = "10.1038/s41467-019-09671-3",

language = "English",

volume = "10",

journal = "Nature Communications",

issn = "2041-1723",

publisher = "Nature Publishing Group",

number = "1",

}

Kupers, LK, Monnereau, C, Sharp, GC, Yousefi, P, Salas, LA, Ghantous, A, Page, CM, Reese, SE, Wilcox, AJ, Czamara, D, Starling, AP, Novoloaca, A, Lent, S, Roy, R, Hoyo, C, Breton, C, Allard, C, Just, AC, Bakulski, KM, Holloway, JW, Everson, TM, Xu, C-J, Huang, R-C, van der Plaat, DA, Wielscher, M, Merid, SK, Ullemar, V, Rezwan, F, Lahti, J, van Dongen, J, Langie, SAS, Richardson, TG, Magnus, MC, Nohr, EA, Xu, Z, Duijts, L, Zhao, S, Zhang, W, Plusquin, M, DeMeo, DL, Solomon, O, Heimovaara, JH, Jima, DD, Gao, L, Bustamante, M, Perron, P, Wright, RO, Hertz-Picciotto, I, Zhang, H, Karagas, MR, Gehring, U, Marsit, CJ, Beilin, LJ, Vonk, JM, Jarvelin, M-R, Bergstrom, A, Ortqvist, AK, Ewart, S, Villa, PM, Moore, SE, Willemsen, G, Standaert, ARL, Haberg, SE, Sorensen, TIA, Taylor, JA, Raikkonen, K, Yang, I, Kechris, K, Nawrot, TS, Silver, MJ, Gong, YY, Richiardi, L, Kogevinas, M, Litonjua, AA, Eskenazi, B, Huen, K, Mbarek, H, Maguire, RL, Dwyer, T, Vrijheid, M, Bouchard, L, Baccarelli, AA, Croen, LA, Karmaus, W, Anderson, D, de Vries, M, Sebert, S, Kere, J, Karlsson, R, Arshad, SH, Hamalainen, E, Routledge, MN, Boomsma, D, Feinberg, AP, Newschaffer, CJ, Govarts, E, Moisse, M, Fallin, MD, Melen, E, Prentice, AM, Kajantie, E, Almqvist, C, Oken, E, Dabelea, D, Boezen, HM, Melton, PE, Wright, RJ, Koppelman, GH, Trevisi, L, Hivert, M-F, Sunyer, J, Munthe-Kaas, MC, Murphy, SK, Corpeleijn, E, Wiemels, J, Holland, N, Herceg, Z, Binder, EB, Smith, GD, Jaddoe, VWV, Lie, RT, Nystad, W, London, SJ, Lawlor, DA, Relton, CL, Snieder, H & Felix, JF 2019, 'Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight', Nature Communications, vol. 10, no. 1, 1893. https://doi.org/10.1038/s41467-019-09671-3

TY - JOUR

T1 - Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight

AU - Kupers, Leanne K.

AU - Monnereau, Claire

AU - Sharp, Gemma C.

AU - Yousefi, Paul

AU - Salas, Lucas A.

AU - Ghantous, Akram

AU - Page, Christian M.

AU - Reese, Sarah E.

AU - Wilcox, Allen J.

AU - Czamara, Darina

AU - Starling, Anne P.

AU - Novoloaca, Alexei

AU - Lent, Samantha

AU - Roy, Ritu

AU - Hoyo, Cathrine

AU - Breton, Carrie

AU - Allard, Catherine

AU - Just, Allan C.

AU - Bakulski, Kelly M.

AU - Holloway, John W.

AU - Everson, Todd M.

AU - Xu, Cheng-Jian

AU - Huang, Rae-Chi

AU - van der Plaat, Diana A.

AU - Wielscher, Matthias

AU - Merid, Simon Kebede

AU - Ullemar, Vilhelmina

AU - Rezwan, Faisal

AU - Lahti, Jari

AU - van Dongen, Jenny

AU - Langie, Sabine A. S.

AU - Richardson, Tom G.

AU - Magnus, Maria C.

AU - Nohr, Ellen A.

AU - Xu, Zongli

AU - Duijts, Liesbeth

AU - Zhao, Shanshan

AU - Zhang, Weiming

AU - Plusquin, Michelle

AU - DeMeo, Dawn L.

AU - Solomon, Olivia

AU - Heimovaara, Joosje H.

AU - Jima, Dereje D.

AU - Gao, Lu

AU - Bustamante, Mariona

AU - Perron, Patrice

AU - Wright, Robert O.

AU - Hertz-Picciotto, Irva

AU - Zhang, Hongmei

AU - Karagas, Margaret R.

AU - Gehring, Ulrike

AU - Marsit, Carmen J.

AU - Beilin, Lawrence J.

AU - Vonk, Judith M.

AU - Jarvelin, Marjo-Riitta

AU - Bergstrom, Anna

AU - Ortqvist, Anne K.

AU - Ewart, Susan

AU - Villa, Pia M.

AU - Moore, Sophie E.

AU - Willemsen, Gonneke

AU - Standaert, Arnout R. L.

AU - Haberg, Siri E.

AU - Sorensen, Thorkild I. A.

AU - Taylor, Jack A.

AU - Raikkonen, Katri

AU - Yang, Ivana

AU - Kechris, Katerina

AU - Nawrot, Tim S.

AU - Silver, Matt J.

AU - Gong, Yun Yun

AU - Richiardi, Lorenzo

AU - Kogevinas, Manolis

AU - Litonjua, Augusto A.

AU - Eskenazi, Brenda

AU - Huen, Karen

AU - Mbarek, Hamdi

AU - Maguire, Rachel L.

AU - Dwyer, Terence

AU - Vrijheid, Martine

AU - Bouchard, Luigi

AU - Baccarelli, Andrea A.

AU - Croen, Lisa A.

AU - Karmaus, Wilfried

AU - Anderson, Denise

AU - de Vries, Maaike

AU - Sebert, Sylvain

AU - Kere, Juha

AU - Karlsson, Robert

AU - Arshad, Syed Hasan

AU - Hamalainen, Esa

AU - Routledge, Michael N.

AU - Boomsma, Dorret

AU - Feinberg, Andrew P.

AU - Newschaffer, Craig J.

AU - Govarts, Eva

AU - Moisse, Matthieu

AU - Fallin, M. Daniele

AU - Melen, Erik

AU - Prentice, Andrew M.

AU - Kajantie, Eero

AU - Almqvist, Catarina

AU - Oken, Emily

AU - Dabelea, Dana

AU - Boezen, H. Marike

AU - Melton, Phillip E.

AU - Wright, Rosalind J.

AU - Koppelman, Gerard H.

AU - Trevisi, Letizia

AU - Hivert, Marie-France

AU - Sunyer, Jordi

AU - Munthe-Kaas, Monica C.

AU - Murphy, Susan K.

AU - Corpeleijn, Eva

AU - Wiemels, Joseph

AU - Holland, Nina

AU - Herceg, Zdenko

AU - Binder, Elisabeth B.

AU - Smith, George Davey

AU - Jaddoe, Vincent W. V.

AU - Lie, Rolv T.

AU - Nystad, Wenche

AU - London, Stephanie J.

AU - Lawlor, Debbie A.

AU - Relton, Caroline L.

AU - Snieder, Harold

AU - Felix, Janine F.

PY - 2019/4/23

Y1 - 2019/4/23

N2 - Birthweight is associated with health outcomes across the life course, DNA methylation may be an underlying mechanism. In this meta-analysis of epigenome-wide association studies of 8,825 neonates from 24 birth cohorts in the Pregnancy And Childhood Epigenetics Consortium, we find that DNA methylation in neonatal blood is associated with birthweight at 914 sites, with a difference in birthweight ranging from -183 to 178 grams per 10% increase in methylation (PBonferroni < 1.06 x 10-7). In additional analyses in 7,278 participants, <1.3% of birthweight-associated differential methylation is also observed in childhood and adolescence, but not adulthood. Birthweight-related CpGs overlap with some Bonferroni-significant CpGs that were previously reported to be related to maternal smoking (55/914, p = 6.12 x 10-74) and BMI in pregnancy (3/914, p = 1.13x10-3), but not with those related to folate levels in pregnancy. Whether the associations that we observe are causal or explained by confounding or fetal growth influencing DNA methylation (i.e. reverse causality) requires further research.

AB - Birthweight is associated with health outcomes across the life course, DNA methylation may be an underlying mechanism. In this meta-analysis of epigenome-wide association studies of 8,825 neonates from 24 birth cohorts in the Pregnancy And Childhood Epigenetics Consortium, we find that DNA methylation in neonatal blood is associated with birthweight at 914 sites, with a difference in birthweight ranging from -183 to 178 grams per 10% increase in methylation (PBonferroni < 1.06 x 10-7). In additional analyses in 7,278 participants, <1.3% of birthweight-associated differential methylation is also observed in childhood and adolescence, but not adulthood. Birthweight-related CpGs overlap with some Bonferroni-significant CpGs that were previously reported to be related to maternal smoking (55/914, p = 6.12 x 10-74) and BMI in pregnancy (3/914, p = 1.13x10-3), but not with those related to folate levels in pregnancy. Whether the associations that we observe are causal or explained by confounding or fetal growth influencing DNA methylation (i.e. reverse causality) requires further research.

KW - MENDELIAN RANDOMIZATION

KW - MATERNAL SMOKING

KW - FETAL ORIGINS

KW - CORD BLOOD

KW - EPIGENETIC MEDIATION

KW - GENETIC-EVIDENCE

KW - PREGNANCY

KW - PACKAGE

KW - DISEASE

KW - BIOCONDUCTOR

U2 - 10.1038/s41467-019-09671-3

DO - 10.1038/s41467-019-09671-3

M3 - Article

C2 - 31015461

SN - 2041-1723

VL - 10

JO - Nature Communications

JF - Nature Communications

IS - 1

M1 - 1893

ER -

Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight

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Datasets

Dataset: Meta-analysis results of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight

Additional file 7 of Developmental programming in human umbilical cord vein endothelial cells following fetal growth restriction

GECKO Drenthe cohort

Cite this