Meta-analysis of genome-wide association for migraine in six population-based European cohorts

Lannie Ligthart; Boukje de Vries; Albert V. Smith; M. Arfan Ikram; Najaf Amin; Jouke-Jan Hottenga; Stephany C. Koelewijn; V. Mathijs Kattenberg; Marleen H. M. de Moor; A. Cecile J. W. Janssens; Yurii S. Aulchenko; Ben A. Oostra; Eco J. C. de Geus; Johannes H. Smit; Frans G. Zitman; Andre G. Uitterlinden; Albert Hofman; Gonneke Willemsen; Dale R. Nyholt; Grant W. Montgomery; Gisela M. Terwindt; Vilmundur Gudnason; Brenda W. J. H. Penninx; Monique Breteler; Michel D. Ferrari; Lenore J. Launer; Cornelia M. van Duijn; Arn M. J. M. van den Maagdenberg; Dorret I. Boomsma; Dutch Icelandic Migraine Genetics

doi:10.1038/ejhg.2011.48

Meta-analysis of genome-wide association for migraine in six population-based European cohorts

Lannie Ligthart^*
, Boukje de Vries
, Albert V. Smith
, M. Arfan Ikram
, Najaf Amin
, Jouke-Jan Hottenga
, Stephany C. Koelewijn
, V. Mathijs Kattenberg
, Marleen H. M. de Moor
, A. Cecile J. W. Janssens
, Yurii S. Aulchenko
, Ben A. Oostra
, Eco J. C. de Geus
, Johannes H. Smit
, Frans G. Zitman
, Andre G. Uitterlinden
, Albert Hofman
, Gonneke Willemsen
, Dale R. Nyholt
, Grant W. Montgomery

Gisela M. Terwindt, Vilmundur Gudnason, Brenda W. J. H. Penninx, Monique Breteler, Michel D. Ferrari, Lenore J. Launer, Cornelia M. van Duijn, Arn M. J. M. van den Maagdenberg, Dorret I. Boomsma, Dutch Icelandic Migraine Genetics

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

88 Citations (Scopus)

Abstract

Migraine is a common neurological disorder with a genetically complex background. This paper describes a meta-analysis of genome-wide association (GWA) studies on migraine, performed by the Dutch-Icelandic migraine genetics (DICE) consortium, which brings together six population-based European migraine cohorts with a total sample size of 10 980 individuals (2446 cases and 8534 controls). A total of 32 SNPs showed marginal evidence for association at a P-value

Original language	English
Pages (from-to)	901-907
Number of pages	7
Journal	European Journal of Human Genetics
Volume	19
Issue number	8
DOIs	https://doi.org/10.1038/ejhg.2011.48
Publication status	Published - Aug-2011

Keywords

migraine
meta-analysis
genome-wide association
population-based
FAMILIAL HEMIPLEGIC MIGRAINE
DELETION POLYMORPHISM
TYPICAL MIGRAINE
COMMON MIGRAINE
CHROMOSOME 4Q24
AURA
GENE
SUSCEPTIBILITY
MTHFR
ENTITIES

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Ligthart, L., de Vries, B., Smith, A. V., Ikram, M. A., Amin, N., Hottenga, J.-J., Koelewijn, S. C., Kattenberg, V. M., de Moor, M. H. M., Janssens, A. C. J. W., Aulchenko, Y. S., Oostra, B. A., de Geus, E. J. C., Smit, J. H., Zitman, F. G., Uitterlinden, A. G., Hofman, A., Willemsen, G., Nyholt, D. R., ... Dutch Icelandic Migraine Genetics (2011). Meta-analysis of genome-wide association for migraine in six population-based European cohorts. European Journal of Human Genetics, 19(8), 901-907. https://doi.org/10.1038/ejhg.2011.48

@article{21ecaee281ce4840a30d4a993d276085,

title = "Meta-analysis of genome-wide association for migraine in six population-based European cohorts",

abstract = "Migraine is a common neurological disorder with a genetically complex background. This paper describes a meta-analysis of genome-wide association (GWA) studies on migraine, performed by the Dutch-Icelandic migraine genetics (DICE) consortium, which brings together six population-based European migraine cohorts with a total sample size of 10 980 individuals (2446 cases and 8534 controls). A total of 32 SNPs showed marginal evidence for association at a P-value",

keywords = "migraine, meta-analysis, genome-wide association, population-based, FAMILIAL HEMIPLEGIC MIGRAINE, DELETION POLYMORPHISM, TYPICAL MIGRAINE, COMMON MIGRAINE, CHROMOSOME 4Q24, AURA, GENE, SUSCEPTIBILITY, MTHFR, ENTITIES",

author = "Lannie Ligthart and \{de Vries\}, Boukje and Smith, \{Albert V.\} and Ikram, \{M. Arfan\} and Najaf Amin and Jouke-Jan Hottenga and Koelewijn, \{Stephany C.\} and Kattenberg, \{V. Mathijs\} and \{de Moor\}, \{Marleen H. M.\} and Janssens, \{A. Cecile J. W.\} and Aulchenko, \{Yurii S.\} and Oostra, \{Ben A.\} and \{de Geus\}, \{Eco J. C.\} and Smit, \{Johannes H.\} and Zitman, \{Frans G.\} and Uitterlinden, \{Andre G.\} and Albert Hofman and Gonneke Willemsen and Nyholt, \{Dale R.\} and Montgomery, \{Grant W.\} and Terwindt, \{Gisela M.\} and Vilmundur Gudnason and Penninx, \{Brenda W. J. H.\} and Monique Breteler and Ferrari, \{Michel D.\} and Launer, \{Lenore J.\} and \{van Duijn\}, \{Cornelia M.\} and \{van den Maagdenberg\}, \{Arn M. J. M.\} and Boomsma, \{Dorret I.\} and \{Dutch Icelandic Migraine Genetics\}",

year = "2011",

month = aug,

doi = "10.1038/ejhg.2011.48",

language = "English",

volume = "19",

pages = "901--907",

journal = "European Journal of Human Genetics",

issn = "1018-4813",

publisher = "Nature Publishing Group",

number = "8",

}

Ligthart, L, de Vries, B, Smith, AV, Ikram, MA, Amin, N, Hottenga, J-J, Koelewijn, SC, Kattenberg, VM, de Moor, MHM, Janssens, ACJW, Aulchenko, YS, Oostra, BA, de Geus, EJC, Smit, JH, Zitman, FG, Uitterlinden, AG, Hofman, A, Willemsen, G, Nyholt, DR, Montgomery, GW, Terwindt, GM, Gudnason, V, Penninx, BWJH, Breteler, M, Ferrari, MD, Launer, LJ, van Duijn, CM, van den Maagdenberg, AMJM, Boomsma, DI & Dutch Icelandic Migraine Genetics 2011, 'Meta-analysis of genome-wide association for migraine in six population-based European cohorts', European Journal of Human Genetics, vol. 19, no. 8, pp. 901-907. https://doi.org/10.1038/ejhg.2011.48

TY - JOUR

T1 - Meta-analysis of genome-wide association for migraine in six population-based European cohorts

AU - Ligthart, Lannie

AU - de Vries, Boukje

AU - Smith, Albert V.

AU - Ikram, M. Arfan

AU - Amin, Najaf

AU - Hottenga, Jouke-Jan

AU - Koelewijn, Stephany C.

AU - Kattenberg, V. Mathijs

AU - de Moor, Marleen H. M.

AU - Janssens, A. Cecile J. W.

AU - Aulchenko, Yurii S.

AU - Oostra, Ben A.

AU - de Geus, Eco J. C.

AU - Smit, Johannes H.

AU - Zitman, Frans G.

AU - Uitterlinden, Andre G.

AU - Hofman, Albert

AU - Willemsen, Gonneke

AU - Nyholt, Dale R.

AU - Montgomery, Grant W.

AU - Terwindt, Gisela M.

AU - Gudnason, Vilmundur

AU - Penninx, Brenda W. J. H.

AU - Breteler, Monique

AU - Ferrari, Michel D.

AU - Launer, Lenore J.

AU - van Duijn, Cornelia M.

AU - van den Maagdenberg, Arn M. J. M.

AU - Boomsma, Dorret I.

AU - Dutch Icelandic Migraine Genetics

PY - 2011/8

Y1 - 2011/8

N2 - Migraine is a common neurological disorder with a genetically complex background. This paper describes a meta-analysis of genome-wide association (GWA) studies on migraine, performed by the Dutch-Icelandic migraine genetics (DICE) consortium, which brings together six population-based European migraine cohorts with a total sample size of 10 980 individuals (2446 cases and 8534 controls). A total of 32 SNPs showed marginal evidence for association at a P-value

AB - Migraine is a common neurological disorder with a genetically complex background. This paper describes a meta-analysis of genome-wide association (GWA) studies on migraine, performed by the Dutch-Icelandic migraine genetics (DICE) consortium, which brings together six population-based European migraine cohorts with a total sample size of 10 980 individuals (2446 cases and 8534 controls). A total of 32 SNPs showed marginal evidence for association at a P-value

KW - migraine

KW - meta-analysis

KW - genome-wide association

KW - population-based

KW - FAMILIAL HEMIPLEGIC MIGRAINE

KW - DELETION POLYMORPHISM

KW - TYPICAL MIGRAINE

KW - COMMON MIGRAINE

KW - CHROMOSOME 4Q24

KW - AURA

KW - GENE

KW - SUSCEPTIBILITY

KW - MTHFR

KW - ENTITIES

U2 - 10.1038/ejhg.2011.48

DO - 10.1038/ejhg.2011.48

M3 - Article

SN - 1018-4813

VL - 19

SP - 901

EP - 907

JO - European Journal of Human Genetics

JF - European Journal of Human Genetics

IS - 8

ER -

Meta-analysis of genome-wide association for migraine in six population-based European cohorts

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Keywords

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