Metabolic consequences of ileal interruption of the enterohepatic circulation of bile acids

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Abstract

The enterohepatic circulation of bile acids comprises a tightly regulated process of hepatic bile acid secretion, intestinal reabsorption and transport back to the liver. Disruption of this process has significant consequences for both gastrointestinal, liver and whole-body homeostasis and therefore offers opportunities for therapeutic intervention. In this review we discuss the effects of (pharmacological) interruption of the enterohepatic circulation at different levels. Recently, several studies have been published on ileal interruption of the enterohepatic circulation of bile acids, targeting the apical-sodium dependent bile acid transporter (ASBT, SLC10A2), as therapy for various diseases. However, ambiguous results have been reported and in-depth mechanistic insights are lacking. Here we discuss these novel studies and review the current knowledge and literature on the consequences of ASBT inhibition and its potential effects on physiology and metabolism.

Original languageEnglish
Pages (from-to)G619-G625
Number of pages7
JournalAmerican Journal of Physiology. Gastrointestinal and Liver Physiology
Volume319
Issue number5
Early online date16-Sep-2020
DOIs
Publication statusPublished - Nov-2020

Keywords

  • ASBT
  • bile acids
  • enterohepatic circulation
  • FXR

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