Metabolic risk in people with psychotic disorders: No mental health without physical health

    Research output: ThesisThesis fully internal (DIV)

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    People with psychotic disorders have an increased metabolic risk and a shortened mean life expectancy compared to the general population. Routine
    outcome monitoring of metabolic risk factors in these patients is therefore recommended and has been implemented in the northern Netherlands for
    several years. This thesis shows that despite regular monitoring, only 43-50% of the patients receives treatment for metabolic risk factors when this is
    recommended by treatment guidelines. One of the factors associated with increased metabolic risk, discussed in this thesis, is vitamin D insufficiency.
    This relation can be explained by a complex model invoking the role of negative symptoms, antipsychotics and an unhealthy lifestyle. Furthermore, this
    thesis demonstrates that cannabis users have a lower BMI, smaller waist circumference and lower diastolic blood pressure, but also more severe psychotic symptoms than non-users. After one year, cannabis discontinuers had a greater increase in BMI, waist circumference, diastolic blood pressure and triglycerides, and a greater decrease in psychotic symptoms than other patients. Patients with a specific AKT1 gene more often used cannabis, but this did not influence the association between cannabis use and BMI. This thesis also shows that patients’ metabolic risk can be decreased according to the lifestyle interventions studied to date (decreased body weight, waist circumference, triglycerides and fasting glucose concentrations), but not remedied (no improvements on blood pressure or cholesterol). This thesis emphasises that monitoring does not automatically result in better care. This suggests we should urgently examine the efficacy of current monitoring, referral and treatment practices.
    Original languageEnglish
    QualificationDoctor of Philosophy
    Awarding Institution
    • University of Groningen
    • Pijnenborg, Marieke, Supervisor
    • van den Heuvel, Edwin, Supervisor
    • Jörg, Frederike, Co-supervisor
    • Bruggeman, Richard, Co-supervisor
    Award date31-Oct-2016
    Place of Publication[Groningen]
    Print ISBNs978-90-367-9099-4
    Electronic ISBNs978-90-367-9098-7
    Publication statusPublished - 2016

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