Method for the production of primary amines

Kai-Uwe Baldenius (Inventor), Klaus Ditrich (Inventor), Michael Breurer (Inventor), Vaidotas Navickas (Inventor), Dick Janssen (Inventor), Sebastian Bartsch (Inventor), Ciprian Crismaru (Inventor)

Research output: Patent

Abstract

The present invention relates to a novel enzymatically catalyzed method for the production of aliphatic primary amines, which method comprises the enzymatic oxidation of a primary aliphatic alcohol catalyzed by an alcohol dehydrogenase, amination of the resulting oxocompound catalyzed by a transaminase and optionally coupled with an enzymatically catalyzed regeneration of the consumed cofactor; recombinant expression systems and microorganisms procuring the required enzyme activities; and bioreactors for performing such methods; as well as the use of the obtained amines in organic synthesis, in particular for preparing organic polymers.
Original languageEnglish
Patent numberWO2014041011
Priority date11/09/2012
Publication statusPublished - 20-Mar-2014

Keywords

  • primary amines
  • alcohol dehydrogenase
  • transaminase

Cite this