Methylone and mCPP, two new drugs of abuse?

MG Bossong*, JP Van Dijk, RJM Niesink

*Corresponding author for this work

Research output: Contribution to journalEditorialAcademicpeer-review

80 Citations (Scopus)

Abstract

Recently, two new ecstasy-like substances, methylone and mCPP, were found in street drugs in the Netherlands by the Drugs Information and Monitoring System (DIMS). Methylone (3,4-methylenedioxymethcathinone) is the main ingredient of a new liquid designer drug that appeared on the Dutch drug market, called. 'Explosion'. mCPP (meta-chloropheizylpiperazine) is a substance often used as a probe for the serotonin function in psychiatric research, and has now been found in street drugs, both in tablets and powders. Methylone as well as mCPP act oil monoantinergic systems, resembling MDAM (3,4-methylenedioxymethaniphetamine), with mCPP mainly affecting the serotonin system. The subjective effects of both new substances exhibit subtle differences with those of MDAM. Only little is known about the harmfulness of both methylone and mCPP. However, because of similarities between these substances and MDAM, risks common to MDMA cannot be excluded.

Original languageEnglish
Pages (from-to)321-323
Number of pages3
JournalAddiction biology
Volume10
Issue number4
DOIs
Publication statusPublished - Dec-2005

Keywords

  • M-CHLOROPHENYLPIPERAZINE MCPP
  • META-CHLOROPHENYLPIPERAZINE
  • 3,4-METHYLENEDIOXYMETHAMPHETAMINE MDMA
  • PHARMACODYNAMIC PROFILE
  • SEROTONIN RELEASE
  • SYNTHETIC DRUG
  • RAT-BRAIN
  • IN-VIVO
  • CHALLENGE
  • 1-(M-CHLOROPHENYL)PIPERAZINE

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