Micro albuminuria, decreased fibrinolysis, and inflammation as early signs of atherosclerosis in long-term survivors of disseminated testicular cancer

J Nuver, AJ Smit, DT Sleijfer, AI van Gessel, AM van Roon, J van der Meer, MP van den Berg, JGM Burgerhof, HJ Hoekstra, WJ Sluiter, JA Gietema*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

107 Citations (Scopus)

Abstract

Testicular cancer patients have an increased risk for coronary artery disease more than ten years after cisplatin-based chemotherapy. We investigated whether vascular changes, including endothelial dysfunction, are present earlier. Ninety chemotherapy-treated testicular cancer patients (median follow-up of seven years) were compared with 44 patients after orchidectomy only and 47 healthy men. Microalbuminuria was present in 10 (12%) chemotherapy patients, one stage I patient and none of the controls. Chemotherapy patients had higher levels of fibrinogen, C-reactive protein (hs-CRP), von Willebrand factor (vWF), plasminogen activator inhibitor (PAI-1), and tissue-type plasminogen activator (t-PA). Chemotherapy patients with elevated PAI-1 (25/90) showed clustering of cardiovascular risk factors resembling the metabolic syndrome. In conclusion, cured testicular cancer patients showed a high prevalence of microalbuminuria and increased plasma levels of endothelial and inflammatory marker proteins, which might progress to more severe endothelial dysfunction and overt atherosclerosis. (C) 2004 Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)701-706
Number of pages6
JournalEuropean Journal of Cancer
Volume40
Issue number5
DOIs
Publication statusPublished - Mar-2004

Keywords

  • testicular neoplasms
  • arteriosclerosis
  • endothelium
  • albuminuria
  • inflammation
  • fibrinolysis
  • plasminogen activator inhibitors
  • von Willebrand Factor
  • INTIMA-MEDIA THICKNESS
  • CARDIOVASCULAR-DISEASE
  • MYOCARDIAL-INFARCTION
  • ENDOTHELIAL-CELLS
  • ARTERIAL-DISEASE
  • CAROTID-ARTERY
  • RISK-FACTORS
  • IN-VITRO
  • MEN
  • CHEMOTHERAPY

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