Microbiology of destructive periodontal disease in adolescent patients with congenital neutropenia - A report of 3 cases

AJ van Winkelhoff*, AYN Schouten-van Meeteren, JA Baart, CMJE Vandenbroucke-Grauls

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

20 Citations (Scopus)

Abstract

Background, aims: Congenital neutropenia is one condition that may predispose for destructive periodontal disease at a young age. In this report, we describe the microbiology of 3 adolescent patients with congenital neutropenia two of whom suffered from severe periodontitis.

Method: Microbiological testing of the parents was also performed in 1 case. DNA fingerprinting was used to study transmission of putative periodontal pathogens in this case. From 1 patient with periodontitis, Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis were isolated; a 2nd periodontitis patient was infected with P. gingivalis. A 3rd patient had gingivitis only and no A. actinomycetemcomitans or P. gingivalis were found.

Results: Using the amplified fragment length polymorphism DNA fingerprinting technique, bacterial transmission between the father and a patient was shown for A. actinomycetemcomitans but not for P. gingivalis.

Original languageEnglish
Pages (from-to)793-798
Number of pages6
JournalJournal of Clinical Periodontology
Volume27
Issue number11
Publication statusPublished - Nov-2000

Keywords

  • periodontitis
  • neutropenia
  • microbiology
  • ACTINOMYCETEMCOMITANS-ASSOCIATED PERIODONTITIS
  • PREPUBERTAL PERIODONTITIS
  • ACTINOBACILLUS-ACTINOMYCETEMCOMITANS
  • PORPHYROMONAS-GINGIVALIS
  • METRONIDAZOLE
  • CHILDREN
  • FAMILY

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