Microbiome Modulation of the Host Adaptive Immunity through Bile Acid Modification

Folkert Kuipers*, Jan Freark de Boer, Bart Staels

*Corresponding author for this work

Research output: Contribution to journalEditorialAcademicpeer-review

1 Citation (Scopus)

Abstract

The microbiome is well known to influence the immune response of the host. Song et al. now show that the microbiome modulates adaptive immunity in mice through formation of bile acid species acting on RORγ+ regulatory T cells via the Vitamin D Receptor, thereby lowering the vulnerability for chemically induced colitis.

Original languageEnglish
Pages (from-to)445-447
Number of pages3
JournalCell metabolism
Volume31
Issue number3
DOIs
Publication statusPublished - 3-Mar-2020

Keywords

  • DEFICIENT
  • RECEPTOR
  • SALTS
  • MICE

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