Microfluidic-Assisted Production of Gastro-Resistant Active-Targeted Diatomite Nanoparticles for the Local Release of Galunisertib in Metastatic Colorectal Cancer Cells (Adv. Healthcare Mater. 6/2023)

Chiara Tramontano; João Pedro Martins; Luca De Stefano; Marianna Kemell; Alexandra Correia; Monica Terracciano; Nicola Borbone; Ilaria Rea; Hélder A. Santos

doi:10.1002/adhm.202370029

Microfluidic-Assisted Production of Gastro-Resistant Active-Targeted Diatomite Nanoparticles for the Local Release of Galunisertib in Metastatic Colorectal Cancer Cells (Adv. Healthcare Mater. 6/2023)

Chiara Tramontano, João Pedro Martins, Luca De Stefano, Marianna Kemell, Alexandra Correia, Monica Terracciano, Nicola Borbone, Ilaria Rea, Hélder A. Santos

Research output: Non-textual form › Digital or Visual Products › Academic

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Abstract

Nanoparticle Drug Delivery

The encapsulation of nanoparticles in hydroxypropyl methyl cellulose is key to treat colorectal cancer through oral administration. In article 2202672 by Ilaria Rea, Hélder A. Santos, and co-workers, gelatin-coated diatomite nanoparticles loaded with galunisertib are functionalized with an anti-L1-CAM antibody that targets metastatic colon cancer cells. These nanoparticles are then encapsulated in a gastro-resistant matrix using microfluidics. When the nanoparticles interact with the targeted cells, the gastro-resistant coating dissolves and galunisertib is released.

Original language	English
DOIs	https://doi.org/10.1002/adhm.202370029
Publication status	Published - 1-Mar-2023

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Microfluidic-Assisted Production of Gastro-Resistant Active-Targeted Diatomite Nanoparticles for the Local Release of Galunisertib in Metastatic Colorectal Cancer Cells (Adv. Healthcare MaterFinal publisher's version, 2.5 MBLicence: Unspecified

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Tramontano, C., Martins, J. P., De Stefano, L., Kemell, M., Correia, A., Terracciano, M., Borbone, N., Rea, I., & Santos, H. A. (2023). Microfluidic-Assisted Production of Gastro-Resistant Active-Targeted Diatomite Nanoparticles for the Local Release of Galunisertib in Metastatic Colorectal Cancer Cells (Adv. Healthcare Mater. 6/2023). Digital or Visual Products https://doi.org/10.1002/adhm.202370029

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title = "Microfluidic-Assisted Production of Gastro-Resistant Active-Targeted Diatomite Nanoparticles for the Local Release of Galunisertib in Metastatic Colorectal Cancer Cells (Adv. Healthcare Mater. 6/2023)",

abstract = "Nanoparticle Drug DeliveryThe encapsulation of nanoparticles in hydroxypropyl methyl cellulose is key to treat colorectal cancer through oral administration. In article 2202672 by Ilaria Rea, H{\'e}lder A. Santos, and co-workers, gelatin-coated diatomite nanoparticles loaded with galunisertib are functionalized with an anti-L1-CAM antibody that targets metastatic colon cancer cells. These nanoparticles are then encapsulated in a gastro-resistant matrix using microfluidics. When the nanoparticles interact with the targeted cells, the gastro-resistant coating dissolves and galunisertib is released.",

author = "Chiara Tramontano and Martins, \{Jo{\~a}o Pedro\} and \{De Stefano\}, Luca and Marianna Kemell and Alexandra Correia and Monica Terracciano and Nicola Borbone and Ilaria Rea and Santos, \{H{\'e}lder A.\}",

note = "https://doi.org/10.1002/adhm.202370029",

year = "2023",

month = mar,

day = "1",

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language = "English",

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Tramontano, C, Martins, JP, De Stefano, L, Kemell, M, Correia, A, Terracciano, M, Borbone, N, Rea, I & Santos, HA, Microfluidic-Assisted Production of Gastro-Resistant Active-Targeted Diatomite Nanoparticles for the Local Release of Galunisertib in Metastatic Colorectal Cancer Cells (Adv. Healthcare Mater. 6/2023), 2023, Digital or Visual Products. https://doi.org/10.1002/adhm.202370029

Microfluidic-Assisted Production of Gastro-Resistant Active-Targeted Diatomite Nanoparticles for the Local Release of Galunisertib in Metastatic Colorectal Cancer Cells (Adv. Healthcare Mater. 6/2023). Tramontano, Chiara (Author); Martins, João Pedro (Author); De Stefano, Luca (Author) et al.. 2023.

Research output: Non-textual form › Digital or Visual Products › Academic

TY - ADVS

T1 - Microfluidic-Assisted Production of Gastro-Resistant Active-Targeted Diatomite Nanoparticles for the Local Release of Galunisertib in Metastatic Colorectal Cancer Cells (Adv. Healthcare Mater. 6/2023)

AU - Tramontano, Chiara

AU - Martins, João Pedro

AU - De Stefano, Luca

AU - Kemell, Marianna

AU - Correia, Alexandra

AU - Terracciano, Monica

AU - Borbone, Nicola

AU - Rea, Ilaria

AU - Santos, Hélder A.

N1 - https://doi.org/10.1002/adhm.202370029

PY - 2023/3/1

Y1 - 2023/3/1

N2 - Nanoparticle Drug DeliveryThe encapsulation of nanoparticles in hydroxypropyl methyl cellulose is key to treat colorectal cancer through oral administration. In article 2202672 by Ilaria Rea, Hélder A. Santos, and co-workers, gelatin-coated diatomite nanoparticles loaded with galunisertib are functionalized with an anti-L1-CAM antibody that targets metastatic colon cancer cells. These nanoparticles are then encapsulated in a gastro-resistant matrix using microfluidics. When the nanoparticles interact with the targeted cells, the gastro-resistant coating dissolves and galunisertib is released.

AB - Nanoparticle Drug DeliveryThe encapsulation of nanoparticles in hydroxypropyl methyl cellulose is key to treat colorectal cancer through oral administration. In article 2202672 by Ilaria Rea, Hélder A. Santos, and co-workers, gelatin-coated diatomite nanoparticles loaded with galunisertib are functionalized with an anti-L1-CAM antibody that targets metastatic colon cancer cells. These nanoparticles are then encapsulated in a gastro-resistant matrix using microfluidics. When the nanoparticles interact with the targeted cells, the gastro-resistant coating dissolves and galunisertib is released.

U2 - 10.1002/adhm.202370029

DO - 10.1002/adhm.202370029

M3 - Digital or Visual Products

VL - 12

ER -

Microfluidic-Assisted Production of Gastro-Resistant Active-Targeted Diatomite Nanoparticles for the Local Release of Galunisertib in Metastatic Colorectal Cancer Cells (Adv. Healthcare Mater. 6/2023)

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