Microglia Activation, Herpes Infection, and NMDA Receptor Inhibition: Common Pathways to Psychosis?

Hans C. Klein; Janine Doorduin; Lot de Witte; Erik de Vries

doi:10.1007/978-3-319-13602-8_12

Microglia Activation, Herpes Infection, and NMDA Receptor Inhibition: Common Pathways to Psychosis?

Hans C. Klein, Janine Doorduin, Lot de Witte, Erik de Vries

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic

Abstract

Microglia are the resident macrophages of the brain. Microglia play important housekeeping roles during brain development and during exposure to psychosocial stress, toxins, and infectious pathogens. The hippocampus is a vulnerable brain region in response to these external stressors. In patients with psychosis, we found a major activation of microglia in the hippocampus, which could explain in part the volume loss of the hippocampus after a psychotic episode of patients. Recent research suggests low-grade replication of herpes simplex virus (HSV) as a potential environmental trigger of microglia activation in schizophrenia. A common mechanism of psychosis is proposed that involves activation of microglia by toxic, auto-immune, or infectious factors, converging to a blockade of the NMDA-NR1 receptor in the hippocampus.

Original language	English
Title of host publication	Immunology and Psychiatry
Subtitle of host publication	From Basic Research to Therapeutic Interventions
Editors	Norbert Müller, Aye-Mu Myint, Markus J. Schwarz
Publisher	Springer
Pages	243-254
Number of pages	12
ISBN (Electronic)	978-3-319-13602-8
ISBN (Print)	978-3-319-13601-1
DOIs	https://doi.org/10.1007/978-3-319-13602-8_12
Publication status	Published - 2015

Publication series

Name	Current Topics in Neurotoxicity
Volume	8

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Klein, H. C., Doorduin, J., de Witte, L., & de Vries, E. (2015). Microglia Activation, Herpes Infection, and NMDA Receptor Inhibition: Common Pathways to Psychosis? In N. Müller, A.-M. Myint, & M. J. Schwarz (Eds.), Immunology and Psychiatry : From Basic Research to Therapeutic Interventions (pp. 243-254). Article Chapter 12 ( Current Topics in Neurotoxicity; Vol. 8). Springer. https://doi.org/10.1007/978-3-319-13602-8_12

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title = "Microglia Activation, Herpes Infection, and NMDA Receptor Inhibition: Common Pathways to Psychosis?",

abstract = "Microglia are the resident macrophages of the brain. Microglia play important housekeeping roles during brain development and during exposure to psychosocial stress, toxins, and infectious pathogens. The hippocampus is a vulnerable brain region in response to these external stressors. In patients with psychosis, we found a major activation of microglia in the hippocampus, which could explain in part the volume loss of the hippocampus after a psychotic episode of patients. Recent research suggests low-grade replication of herpes simplex virus (HSV) as a potential environmental trigger of microglia activation in schizophrenia. A common mechanism of psychosis is proposed that involves activation of microglia by toxic, auto-immune, or infectious factors, converging to a blockade of the NMDA-NR1 receptor in the hippocampus. ",

author = "Klein, {Hans C.} and Janine Doorduin and {de Witte}, Lot and {de Vries}, Erik",

year = "2015",

doi = "10.1007/978-3-319-13602-8_12",

language = "English",

isbn = "978-3-319-13601-1",

series = " Current Topics in Neurotoxicity",

publisher = "Springer",

pages = "243--254",

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booktitle = "Immunology and Psychiatry",

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Klein, HC , Doorduin, J, de Witte, L & de Vries, E 2015, Microglia Activation, Herpes Infection, and NMDA Receptor Inhibition: Common Pathways to Psychosis? in N Müller, A-M Myint & MJ Schwarz (eds), Immunology and Psychiatry : From Basic Research to Therapeutic Interventions., Chapter 12, Current Topics in Neurotoxicity, vol. 8, Springer, pp. 243-254. https://doi.org/10.1007/978-3-319-13602-8_12

Microglia Activation, Herpes Infection, and NMDA Receptor Inhibition: Common Pathways to Psychosis? / Klein, Hans C.; Doorduin, Janine; de Witte, Lot et al.
Immunology and Psychiatry : From Basic Research to Therapeutic Interventions. ed. / Norbert Müller; Aye-Mu Myint; Markus J. Schwarz. Springer, 2015. p. 243-254 Chapter 12 ( Current Topics in Neurotoxicity; Vol. 8).

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic

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T1 - Microglia Activation, Herpes Infection, and NMDA Receptor Inhibition

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AU - de Witte, Lot

AU - de Vries, Erik

PY - 2015

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N2 - Microglia are the resident macrophages of the brain. Microglia play important housekeeping roles during brain development and during exposure to psychosocial stress, toxins, and infectious pathogens. The hippocampus is a vulnerable brain region in response to these external stressors. In patients with psychosis, we found a major activation of microglia in the hippocampus, which could explain in part the volume loss of the hippocampus after a psychotic episode of patients. Recent research suggests low-grade replication of herpes simplex virus (HSV) as a potential environmental trigger of microglia activation in schizophrenia. A common mechanism of psychosis is proposed that involves activation of microglia by toxic, auto-immune, or infectious factors, converging to a blockade of the NMDA-NR1 receptor in the hippocampus.

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M3 - Chapter

SN - 978-3-319-13601-1

T3 - Current Topics in Neurotoxicity

SP - 243

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BT - Immunology and Psychiatry

A2 - Müller, Norbert

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PB - Springer

ER -

Klein HC , Doorduin J, de Witte L, de Vries E. Microglia Activation, Herpes Infection, and NMDA Receptor Inhibition: Common Pathways to Psychosis? In Müller N, Myint AM, Schwarz MJ, editors, Immunology and Psychiatry : From Basic Research to Therapeutic Interventions. Springer. 2015. p. 243-254. Chapter 12. ( Current Topics in Neurotoxicity). doi: 10.1007/978-3-319-13602-8_12

Microglia Activation, Herpes Infection, and NMDA Receptor Inhibition: Common Pathways to Psychosis?

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