Microglia alterations in neurodegenerative diseases and their modeling with human induced pluripotent stem cell and other platforms

Angélica María Sabogal-Guáqueta, Alejandro Marmolejo-Garza, Vítor Passos de Pádua, Bart Eggen, Erik Boddeke, Amalia M Dolga*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

7 Citations (Scopus)
77 Downloads (Pure)

Abstract

Microglia are the main innate immune cells of the central nervous system (CNS). Unlike neurons and glial cells, which derive from ectoderm, microglia migrate early during embryo development from the yolk-sac, a mesodermal-derived structure. Microglia regulate synaptic pruning during development and induce or modulate inflammation during aging and chronic diseases. Microglia are sensitive to brain injuries and threats, altering their phenotype and function to adopt a so-called immune-activated state in response to any perceived threat to the CNS integrity. Here, we present a short overview on the role of microglia in human neurodegenerative diseases and provide an update on the current model systems to study microglia, including cell lines, iPSC-derived microglia with an emphasis in their transcriptomic profile and integration into 3D brain organoids. We present various strategies to model and study their role in neurodegeneration providing a relevant platform for the development of novel and more effective therapies.

Original languageEnglish
Article number101805
Number of pages17
JournalProgress in Neurobiology
Volume190
Early online date24-Apr-2020
DOIs
Publication statusPublished - Jul-2020

Keywords

  • Microglia
  • iPSC
  • Neurodegenerative diseases
  • Organoids
  • Transcriptomics
  • CENTRAL-NERVOUS-SYSTEM
  • ALZHEIMERS-DISEASE
  • PARKINSONS-DISEASE
  • BRAIN-DEVELOPMENT
  • MOUSE MODEL
  • MITOCHONDRIAL DYSFUNCTION
  • GENE-EXPRESSION
  • TAU PATHOLOGY
  • ACTIVATION
  • DIFFERENTIATION

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