Microglial imaging with positron emission tomography and atrophy measurements with magnetic resonance imaging in multiple sclerosis: a correlative study

J Versijpt, JC Debruyne*, KJ Van Laere, F De Vos, J Keppens, K Strijckmans, E Achten, G Slegers, RA Dierckx, J Korf, JL De Reuck

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

    93 Citations (Scopus)

    Abstract

    Objective: The objectives of the present study were to assess brain atrophy in multiple sclerosis (MS) patients during different disease stages and to investigate by PET and [C-11]PK11195, a marker of microglial activation, the relationship between inflammation, atrophy and clinically relevant measures. Methods: Eight healthy subjects and 22 MS patients were included. Semiquantitative [C-11] PK11195 uptake values, with normalization on cortical grey matter, were measured for magnetic resonance imaging T-2- and T-1-lesions and normal appearing white matter (NAWM). As atrophy index we used the ratio of the amount of white and grey matter divided by the ventricular size, using an optimized a priori based segmentation algorithm (SPM99). Results: Atrophy was significantly greater in MS patients compared to age-matched controls. A significant correlation was found between brain atrophy and both disease duration and disability, as measured with the Expanded Disability Status Scale. For NAWM, [C-11] PK11195 uptake increased with the amount of atrophy, while T-2-lesional [C-11] PK11195 uptake values decreased according to increasing brain atrophy. Conclusions: The present study suggests that brain atrophy, correlating with disease duration and disability, is directly related to NAWM and T-2-lesional inflammation as measured by microglial activation.

    Original languageEnglish
    Pages (from-to)127-134
    Number of pages8
    JournalMultiple sclerosis journal
    Volume11
    Issue number2
    DOIs
    Publication statusPublished - 2005

    Keywords

    • atrophy
    • [11C] PK11195
    • inflammation
    • microglia
    • multiple sclerosis
    • positron emission tomography
    • APPEARING WHITE-MATTER
    • EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS
    • PERIPHERAL BENZODIAZEPINE-RECEPTOR
    • MYELIN-ASSOCIATED GLYCOPROTEIN
    • RELAPSING-REMITTING MS
    • WHOLE-BRAIN ATROPHY
    • BINDING-SITES
    • AXONAL DAMAGE
    • IN-VIVO
    • MOLECULAR-MECHANISMS

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