Milk lipid composition and structure: The relevance for infant brain development

Lidewij Schipper*, Gertjan van Dijk, Eline M. van der Beek

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

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Abstract

The neurocognitive development of infants can be positively associated with breastfeeding exclusivity and duration. Differences in dietary lipid quality between human milk and infant milk formula may contribute to this effect. In this review, we describe some of the known differences between human milk and infant milk formula in lipid quality, including fatty acid composition, complex lipids in the milk fat globule membrane as well as the physical properties of lipids and lipid globules. We describe some of the underlying mechanism by which these aspects of lipid quality are thought to modulate infant brain development such as differences in the supply and/or the bioavailability of lipids, lipid bound components and peripheral organ derived neurodevelopmental signals to the infant brain after ingestion and on longer term.

Original languageEnglish
Article number5
Number of pages11
JournalOcl-Oilseeds and fats crops and lipids
Volume27
DOIs
Publication statusPublished - 28-Jan-2020

Keywords

  • human milk
  • infant milk formula
  • lipid composition
  • lipid structure
  • infant brain development
  • POLYUNSATURATED FATTY-ACIDS
  • ALPHA-LINOLENIC ACID
  • LONG-TERM SUPPLEMENTATION
  • DOCOSAHEXAENOIC ACID
  • GLOBULE-MEMBRANE
  • BREAST-MILK
  • COGNITIVE-DEVELOPMENT
  • COMPLEX LIPIDS
  • WHITE-MATTER
  • SIALIC-ACID

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