Mimicry of a Non-ribosomally Produced Antimicrobial, Brevicidine, by Ribosomal Synthesis and Post-translational Modification

Xinghong Zhao, Zhibo Li, Oscar P Kuipers*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)
83 Downloads (Pure)

Abstract

Zhao et al. describe a strategy to synthesize mimics of the recently discovered antimicrobial non-ribosomal peptide, brevicidine. The engineered mimics show antimicrobial activities against pathogens susceptible to brevicidine, which demonstrate that conversion of NRPs to RiPPs is feasible and offer great opportunities for engineering a wide range of effective antibiotics.

Original languageEnglish
Pages (from-to)1262-1271
Number of pages10
JournalCell Chemical Biology
Volume27
Issue number10
Early online date19-Jul-2020
DOIs
Publication statusPublished - 15-Oct-2020

Keywords

  • Mimicry
  • NRPs
  • RiPPs
  • antimicrobials
  • biosynthetic
  • brevicidine
  • lanthipeptide

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