Mimicry of a Non-ribosomally Produced Antimicrobial, Brevicidine, by Ribosomal Synthesis and Post-translational Modification

Xinghong Zhao; Zhibo Li; Oscar P Kuipers

doi:10.1016/j.chembiol.2020.07.005

Mimicry of a Non-ribosomally Produced Antimicrobial, Brevicidine, by Ribosomal Synthesis and Post-translational Modification

Xinghong Zhao, Zhibo Li, Oscar P Kuipers^*

^*Corresponding author for this work

Molecular Genetics

Research output: Contribution to journal › Article › Academic › peer-review

7 Citations (Scopus)

83 Downloads (Pure)

Abstract

Zhao et al. describe a strategy to synthesize mimics of the recently discovered antimicrobial non-ribosomal peptide, brevicidine. The engineered mimics show antimicrobial activities against pathogens susceptible to brevicidine, which demonstrate that conversion of NRPs to RiPPs is feasible and offer great opportunities for engineering a wide range of effective antibiotics.

Original language	English
Pages (from-to)	1262-1271
Number of pages	10
Journal	Cell Chemical Biology
Volume	27
Issue number	10
Early online date	19-Jul-2020
DOIs	https://doi.org/10.1016/j.chembiol.2020.07.005
Publication status	Published - 15-Oct-2020

Keywords

Mimicry
NRPs
RiPPs
antimicrobials
biosynthetic
brevicidine
lanthipeptide

Access to Document

10.1016/j.chembiol.2020.07.005

Mimicry of a Non-ribosomally Produced Antimicrobial, Brevicidine, by Ribosomal Synthesis and Post-translational ModificationFinal publisher's version, 2.72 MBLicence: Taverne

Cite this

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title = "Mimicry of a Non-ribosomally Produced Antimicrobial, Brevicidine, by Ribosomal Synthesis and Post-translational Modification",

abstract = "Zhao et al. describe a strategy to synthesize mimics of the recently discovered antimicrobial non-ribosomal peptide, brevicidine. The engineered mimics show antimicrobial activities against pathogens susceptible to brevicidine, which demonstrate that conversion of NRPs to RiPPs is feasible and offer great opportunities for engineering a wide range of effective antibiotics.",

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