Abstract
Zhao et al. describe a strategy to synthesize mimics of the recently discovered antimicrobial non-ribosomal peptide, brevicidine. The engineered mimics show antimicrobial activities against pathogens susceptible to brevicidine, which demonstrate that conversion of NRPs to RiPPs is feasible and offer great opportunities for engineering a wide range of effective antibiotics.
Original language | English |
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Pages (from-to) | 1262-1271 |
Number of pages | 10 |
Journal | Cell Chemical Biology |
Volume | 27 |
Issue number | 10 |
Early online date | 19-Jul-2020 |
DOIs | |
Publication status | Published - 15-Oct-2020 |
Keywords
- Mimicry
- NRPs
- RiPPs
- antimicrobials
- biosynthetic
- brevicidine
- lanthipeptide